9ZD1 image
Deposition Date 2025-11-24
Release Date 2026-08-05
Last Version Date 2026-08-05
Entry Detail
PDB ID:
9ZD1
Keywords:
NUCLEAR PROTEIN
Title:
Cryo-EM structure of ATR-ATRIP-TOPBP1 AAD
Biological Source:
Source Organism(s):
Homo sapiens (Taxon ID: 9606)
Expression System(s):
Homo sapiens, Escherichia coli
Method Details:
Experimental Method:
ELECTRON MICROSCOPY
Resolution:
3.20 Å
Aggregation State:
PARTICLE
Reconstruction Method:
SINGLE PARTICLE
9ZD1 validation report missing
Macromolecular Entities
Polymer Type:polypeptide(L)
Molecule:Serine/threonine-protein kina
Chain IDs:A, B
Chain Length:2663
Number of Molecules:2
Biological Source:Homo sapiens
Polymer Type:polypeptide(L)
Molecule:ATR-interacting protein
Chain IDs:C, D
Chain Length:810
Number of Molecules:2
Biological Source:Homo sapiens
Polymer Type:polypeptide(L)
Molecule:DNA topoisomerase 2-binding p
Chain IDs:E (auth: I), F (auth: J)
Chain Length:219
Number of Molecules:2
Biological Source:Homo sapiens
Ligand Molecules
ANP
MG
ZN
Primary Citation
Structural mechanism of TOPBP1 activating the ATR-ATRIP replication checkpoint kinase.
Nat.Struct.Mol.Biol. ? ? ? (2026)
PMID: 42493622 DOI: 10.1038/s41594-026-01844-1
Primary Citation of related structures
9ZD1
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