9ZBJ image
Deposition Date 2025-11-20
Release Date 2026-04-15
Last Version Date 2026-04-15
Entry Detail
PDB ID:
9ZBJ
Keywords:
TRANSFERASE
Title:
Cryo-EM structure of human apo mTORC2
Biological Source:
Source Organism(s):
Homo sapiens (Taxon ID: 9606)
Expression System(s):
Spodoptera frugiperda
Method Details:
Experimental Method:
ELECTRON MICROSCOPY
Resolution:
3.20 Å
Aggregation State:
PARTICLE
Reconstruction Method:
SINGLE PARTICLE
9ZBJ validation report
Macromolecular Entities
Structures with similar UniProt ID
Protein Blast
Polymer Type:polypeptide(L)
Molecule:Serine/threonine-protein kina
Gene (Uniprot):MTOR
Chain IDs:A
Chain Length:2347
Number of Molecules:1
Biological Source:Homo sapiens
UniProt ID:P42345 Pfam ID:PF11865, PF02259, PF23593, PF08771, PF00454, PF02260
Structures with similar UniProt ID
Protein Blast
Polymer Type:polypeptide(L)
Molecule:Target of rapamycin complex s
Gene (Uniprot):MLST8
Chain IDs:B
Chain Length:317
Number of Molecules:1
Biological Source:Homo sapiens
UniProt ID:Q9BVC4 Pfam ID:PF00400
Structures with similar UniProt ID
Protein Blast
Polymer Type:polypeptide(L)
Molecule:Rapamycin-insensitive compani
Gene (Uniprot):RICTOR
Chain IDs:C
Chain Length:1672
Number of Molecules:1
Biological Source:Homo sapiens
UniProt ID:Q6R327 Pfam ID:PF14664, PF14666, PF14663, PF14668, PF14665
Structures with similar UniProt ID
Protein Blast
Polymer Type:polypeptide(L)
Molecule:Target of rapamycin complex 2
Gene (Uniprot):MAPKAP1
Chain IDs:D
Chain Length:148
Number of Molecules:1
Biological Source:Homo sapiens
UniProt ID:Q9BPZ7 Pfam ID:PF05422
Ligand Molecules
ZN
Primary Citation
Structural basis for the recruitment and selective phosphorylation of Akt by mTORC2.
Science 391 eadv7111 eadv7111 (2026)
PMID: 41308123 DOI: 10.1126/science.adv7111
Primary Citation of related structures
9ZBJ
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