9ZBC image
Deposition Date 2025-11-20
Release Date 2026-09-09
Last Version Date 2026-10-21
Entry Detail
PDB ID:
9ZBC
Keywords:
TRANSFERASE/INHIBITOR
Title:
Human GGPPS in the Open Hexamer Conformation
Biological Source:
Source Organism(s):
Homo sapiens (Taxon ID: 9606)
Expression System(s):
Escherichia coli
Method Details:
Experimental Method:
ELECTRON MICROSCOPY
Resolution:
2.25 Å
Aggregation State:
PARTICLE
Reconstruction Method:
SINGLE PARTICLE
9ZBC validation report missing
Macromolecular Entities
Structures with similar UniProt ID
Structural Superimposition Protein Blast
Polymer Type:polypeptide(L)
Molecule:Geranylgeranyl pyrophosphate
Gene (Uniprot):GGPS1
Chain IDs:A, B, C, D (auth: E), E (auth: F), F (auth: G)
Chain Length:301
Number of Molecules:6
Biological Source:Homo sapiens
UniProt ID:O95749 Pfam ID:PF00348 EC:2.5.1.29
Primary Citation
Structural and Functional Analysis of GGPPS Inhibition as a Therapeutic Mechanism for Acute Myeloid Leukemia
J.Med.Chem. 69 21862 21878 (2026)
DOI: 10.1021/acs.jmedchem.6c00808
Primary Citation of related structures
9ZBC
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