9ZB8 image
Deposition Date 2025-11-20
Release Date 2026-09-09
Last Version Date 2026-10-21
Entry Detail
PDB ID:
9ZB8
Keywords:
TRANSFERASE/INHIBITOR
Title:
Crystal Structure of Human GGPPS Bound to Selective Inhibitor CML-07-119
Biological Source:
Source Organism(s):
Homo sapiens (Taxon ID: 9606)
Expression System(s):
Escherichia coli
Method Details:
Experimental Method:
X-RAY DIFFRACTION
Resolution:
2.64 Å
R-Value Free:
0.24
R-Value Work:
0.20
Space Group:
P 1 21 1
9ZB8 validation report missing
Macromolecular Entities
Structures with similar UniProt ID
Structural Superimposition Protein Blast
Polymer Type:polypeptide(L)
Molecule:Geranylgeranyl pyrophosphate
Gene (Uniprot):GGPS1
Chain IDs:A, B, C, D, E, F, G, H, I, J, K, L
Chain Length:301
Number of Molecules:12
Biological Source:Homo sapiens
UniProt ID:O95749 Pfam ID:PF00348 EC:2.5.1.29
Ligand Molecules
A1C1E
MG
Primary Citation
Structural and Functional Analysis of GGPPS Inhibition as a Therapeutic Mechanism for Acute Myeloid Leukemia
J.Med.Chem. 69 21862 21878 (2026)
DOI: 10.1021/acs.jmedchem.6c00808
Primary Citation of related structures
9ZB8
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