ISDA: 9ZB5

Deposition Date 2025-11-20

Release Date 2026-06-10

Last Version Date 2026-06-10

Entry Detail

PDB ID:

9ZB5

Keywords:

VIRAL PROTEIN/IMMUNE SYSTEM

Title:

Cryo-EM structure of the parainfluenza virus hemagglutinin-neuraminidase protein in complex with the human antibodies PIV3HN-05 and PIV3HN-13

Biological Source:

Source Organism(s):

Homo sapiens (Taxon ID: 9606)
Human respirovirus 3 (Taxon ID: 11216)

Expression System(s):

Homo sapiens

Method Details:

Experimental Method:

ELECTRON MICROSCOPY

Resolution:

3.29 Å

Aggregation State:

PARTICLE

Reconstruction Method:

SINGLE PARTICLE

Download Validation Report

Macromolecular Entities

Protein Blast

Polymer Type:polypeptide(L)
Molecule:PIV3HN-05 heavy chain
Chain IDs:A (auth: C), B (auth: D)
Chain Length:249
Number of Molecules:2
Biological Source:Homo sapiens

Protein Blast

Polymer Type:polypeptide(L)
Molecule:PIV3HN-05 light chain
Chain IDs:C (auth: E), F (auth: H)
Chain Length:217
Number of Molecules:2
Biological Source:Homo sapiens

Structures with similar UniProt ID

Protein Blast

Polymer Type:polypeptide(L)
Molecule:Hemagglutinin-neuraminidase
Gene (Uniprot):HN
Chain IDs:D (auth: F), H (auth: J)
Chain Length:461
Number of Molecules:2
Biological Source:Human respirovirus 3

UniProt ID:Q81080

Protein Blast

Polymer Type:polypeptide(L)
Molecule:PIV3HN-13 heavy chain
Chain IDs:E (auth: G), I (auth: M)
Chain Length:240
Number of Molecules:2
Biological Source:Homo sapiens

Protein Blast

Polymer Type:polypeptide(L)
Molecule:PIV3HN-13 light chain
Chain IDs:G (auth: I), J (auth: N)
Chain Length:218
Number of Molecules:2
Biological Source:Homo sapiens

Ligand Molecules

FUC

Primary Citation

Structural Insights into HN-Targeted Monoclonal Antibodies against Human Parainfluenza Virus Type 3

McCaffrey, K.D, Mousa, J.J.Show

To Be Published ? ? ? (?)

Primary Citation of related structures

Feedback Form