ISDA: 9Z70

Deposition Date 2025-11-14

Release Date 2026-01-07

Last Version Date 2026-07-22

Entry Detail

PDB ID:

9Z70

Keywords:

PROTEIN BINDING

Title:

Crystal structure of shorter construct of SHP2 unbound N-SH2 domain (Y66 in blocking conformation)

Biological Source:

Source Organism(s):

Homo sapiens (Taxon ID: 9606)

Expression System(s):

Escherichia coli bl21(de3)

Method Details:

Experimental Method:

X-RAY DIFFRACTION

Resolution:

1.73 Å

R-Value Free:

0.23

R-Value Work:

0.19

R-Value Observed:

0.19

Space Group:

P 43 21 2

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Macromolecular Entities

Structures with similar UniProt ID

Structural Superimposition Protein Blast

Polymer Type:polypeptide(L)
Molecule:Isoform 1 of Tyrosine-protein
Gene (Uniprot):PTPN11
Chain IDs:A
Chain Length:104
Number of Molecules:1
Biological Source:Homo sapiens

UniProt ID:Q06124 Pfam ID:PF00017 EC:3.1.3.48

Primary Citation

Phosphatase SHP2 pathogenic mutations enhance activity by altering conformational sampling.

Glaser, A.W, Padua, R.A.P, Ojoawo, A.M, Sullivan, C, Kern, D.Show

Proc.Natl.Acad.Sci.USA 123 e2513851123 e2513851123 (2026)

PMID: 41528873 DOI: 10.1073/pnas.2513851123

Primary Citation of related structures

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