ISDA: 9Z6E

Deposition Date 2025-11-14

Release Date 2026-07-22

Last Version Date 2026-07-22

Entry Detail

PDB ID:

9Z6E

Keywords:

SIGNALING PROTEIN

Title:

Crystal structure of apo LIMK1 mutant D460N

Biological Source:

Source Organism(s):

Homo sapiens (Taxon ID: 9606)

Expression System(s):

Spodoptera aff. frugiperda 1 bold-2017

Method Details:

Experimental Method:

X-RAY DIFFRACTION

Resolution:

2.26 Å

R-Value Free:

0.24

R-Value Work:

0.19

R-Value Observed:

0.19

Space Group:

P 1 21 1

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Macromolecular Entities

Structures with similar UniProt ID

Structural Superimposition Protein Blast

Polymer Type:polypeptide(L)
Molecule:LIM domain kinase 1
Gene (Uniprot):LIMK1
Mutagens:D460N
Chain IDs:A, B
Chain Length:313
Number of Molecules:2
Biological Source:Homo sapiens

UniProt ID:P53667 Pfam ID:PF07714 EC:2.7.11.1

Primary Citation

A covalent inhibitor targeting Cys-349 of LIMK1 confers selectivity over LIMK2.

Patteson, J.B, Manolaridis, I, Hong, M.R, Johnston, J.M, Mesbahi-Vasey, S, Gregory, M.C, Iwamoto, D.V, Reid, J.C, Sanders, J.M, Lovatt, D, McDonald, T.P, Shurtleff, V.W, Gabelli, S.B, Bukhtiyarova, M.Show

J.Biol.Chem. ? 113322 113322 (2026)

PMID: 42442493 DOI: 10.1016/j.jbc.2026.113322

Primary Citation of related structures

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