ISDA: 9Z5Y

Deposition Date 2025-11-13

Release Date 2026-04-22

Last Version Date 2026-04-22

Entry Detail

PDB ID:

9Z5Y

Keywords:

TOXIN

Title:

Crystal structure of Bothrops pirajai myotoxin I PrTX-I complexed with inhibitor AZD2716

Biological Source:

Source Organism(s):

Bothrops pirajai (Taxon ID: 113192)

Method Details:

Experimental Method:

X-RAY DIFFRACTION

Resolution:

2.75 Å

R-Value Free:

0.26

R-Value Work:

0.24

R-Value Observed:

0.24

Space Group:

P 21 21 21

Download Validation Report

Macromolecular Entities

Structures with similar UniProt ID

Protein Blast

Polymer Type:polypeptide(L)
Molecule:Basic phospholipase A2 homolo
Chain IDs:A, B
Chain Length:121
Number of Molecules:2
Biological Source:Bothrops pirajai

UniProt ID:P58399 EC:3.1.1.4

Ligand Molecules

A1C06

SO4

Primary Citation

Structural and pharmacological analysis of a PLA 2 -like toxin in complex with the sPLA 2 inhibitor AZD2716: Comparisons to varespladib.

Salvador, G.H.M, Pereira, E.S, Cavalcante, W.L.G, Ortolani, P.L, Fortes-Dias, C.L, Lomonte, B, Lewin, M.R, Fontes, M.R.M.Show

Biochimie 245 120 131 (2026)

PMID: 41881275 DOI: 10.1016/j.biochi.2026.03.006

Primary Citation of related structures

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