9Z3V image
Deposition Date 2025-11-07
Release Date 2026-05-13
Last Version Date 2026-05-13
Entry Detail
PDB ID:
9Z3V
Keywords:
APOPTOSIS
Title:
Histidine-covalent 165G1 targeting hMcl-1
Biological Source:
Source Organism(s):
Homo sapiens (Taxon ID: 9606)
synthetic construct (Taxon ID: 32630)
Expression System(s):
Escherichia coli
Method Details:
Experimental Method:
X-RAY DIFFRACTION
Resolution:
1.60 Å
R-Value Free:
0.25
R-Value Work:
0.22
R-Value Observed:
0.22
Space Group:
P 1 21 1
9Z3V validation report missing
Macromolecular Entities
Structures with similar UniProt ID
Protein Blast
Polymer Type:polypeptide(L)
Molecule:Induced myeloid leukemia cell
Gene (Uniprot):MCL1
Chain IDs:A, C (auth: B)
Chain Length:155
Number of Molecules:2
Biological Source:Homo sapiens
UniProt ID:Q07820 Pfam ID:PF00452
Structures with similar UniProt ID
Protein Blast
Polymer Type:polypeptide(L)
Molecule:165G1
Chain IDs:B (auth: C), D
Chain Length:14
Number of Molecules:2
Biological Source:synthetic construct
UniProt ID:9Z3V
Primary Citation
Covalent Targeting of Histidine Residues: A Ligand-First Approach.
J.Med.Chem. ? ? ? (2026)
PMID: 42054250 DOI: 10.1021/acs.jmedchem.5c03255
Primary Citation of related structures
9Z3V
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