ISDA: 9Z3K

Deposition Date 2025-11-07

Release Date 2026-05-13

Last Version Date 2026-05-13

Entry Detail

PDB ID:

9Z3K

Keywords:

VIRAL PROTEIN

Title:

SARS-CoV-2 S2 trimer stabilized in the early fusion intermediate conformation by circular permutation and clamping by gp41 (E-FICs-v1)

Biological Source:

Source Organism(s):

Severe acute respiratory syndrome coronavirus 2 (Taxon ID: 2697049)

Expression System(s):

Homo sapiens

Method Details:

Experimental Method:

ELECTRON MICROSCOPY

Resolution:

3.30 Å

Aggregation State:

PARTICLE

Reconstruction Method:

SINGLE PARTICLE

Download Validation Report

Macromolecular Entities

Protein Blast

Polymer Type:polypeptide(L)
Molecule:SPIKE PROTEIN
Gene (Uniprot):S, SMT3
Chain IDs:A, B, C
Chain Length:608
Number of Molecules:3
Biological Source:Severe acute respiratory syndrome coronavirus 2

UniProt ID:Q12306,P0DTC2 Pfam ID:PF00240, PF01601

Ligand Molecules

NAG

Primary Citation

TMPRSS2-mediated coronavirus spike activation and inhibition.

McCallum, M, Case, J.B, Brown, J.T, Park, Y.J, Lee, J, Sutherland, E, Aggarwal, A, Gibson, C, Lempp, F.A, Stewart, C, Tortorici, M.A, Sanapala, S, Low, J.S, Asarnow, D, Bohan, D, Dellota Jr, E, Merz, B, Chawla, B, Kar, S, Lanzavecchia, A, Sallusto, F, Riley, N.M, Turville, S, Purcell, L, Diamond, M.S, Veesler, D.Show

Nat.Struct.Mol.Biol. ? ? ? (2026)

PMID: 42050172 DOI: 10.1038/s41594-026-01801-y

Primary Citation of related structures

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