ISDA: 9Z3J

Deposition Date 2025-11-06

Release Date 2026-05-13

Last Version Date 2026-05-13

Entry Detail

PDB ID:

9Z3J

Keywords:

VIRAL PROTEIN/Immune System

Title:

HCoV-NL63 S2' peptide bound to TMPRSS2 S441A (complexed with the H1H7 Fab and an anti-kappa-nanobody)

Biological Source:

Source Organism(s):

Human coronavirus NL63 (Taxon ID: 277944)
Homo sapiens (Taxon ID: 9606)
Lama glama (Taxon ID: 9844)

Expression System(s):

Homo sapiens, Escherichia coli

Method Details:

Experimental Method:

ELECTRON MICROSCOPY

Resolution:

2.80 Å

Aggregation State:

PARTICLE

Reconstruction Method:

SINGLE PARTICLE

Download Validation Report

Macromolecular Entities

Structures with similar UniProt ID

Protein Blast

Polymer Type:polypeptide(L)
Molecule:HCoV-NL63 S2' peptide
Gene (Uniprot):S
Chain IDs:A
Chain Length:15
Number of Molecules:1
Biological Source:Human coronavirus NL63

UniProt ID:Q6Q1S2

Structures with similar UniProt ID

Protein Blast

Polymer Type:polypeptide(L)
Molecule:Inactive TMPRSS2 construct
Gene (Uniprot):TMPRSS2
Mutagens:S441A
Chain IDs:B
Chain Length:519
Number of Molecules:1
Biological Source:Homo sapiens

UniProt ID:O15393 Pfam ID:PF15494, PF00089 EC:3.4.21.B60

Structures with similar UniProt ID

Protein Blast

Polymer Type:polypeptide(L)
Molecule:H1H7 heavy chain
Chain IDs:C (auth: H)
Chain Length:223
Number of Molecules:1
Biological Source:Homo sapiens

UniProt ID:9Z3J

Structures with similar UniProt ID

Protein Blast

Polymer Type:polypeptide(L)
Molecule:H1H7 light chain
Chain IDs:D (auth: L)
Chain Length:214
Number of Molecules:1
Biological Source:Homo sapiens

UniProt ID:9Z3J

Structures with similar UniProt ID

Protein Blast

Polymer Type:polypeptide(L)
Molecule:anti-kappa nanobody
Chain IDs:E (auth: N)
Chain Length:159
Number of Molecules:1
Biological Source:Lama glama

UniProt ID:9Z3J

Primary Citation

TMPRSS2-mediated coronavirus spike activation and inhibition.

McCallum, M, Case, J.B, Brown, J.T, Park, Y.J, Lee, J, Sutherland, E, Aggarwal, A, Gibson, C, Lempp, F.A, Stewart, C, Tortorici, M.A, Sanapala, S, Low, J.S, Asarnow, D, Bohan, D, Dellota Jr, E, Merz, B, Chawla, B, Kar, S, Lanzavecchia, A, Sallusto, F, Riley, N.M, Turville, S, Purcell, L, Diamond, M.S, Veesler, D.Show

Nat.Struct.Mol.Biol. ? ? ? (2026)

PMID: 42050172 DOI: 10.1038/s41594-026-01801-y

Primary Citation of related structures

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