ISDA: 9Z3C

Deposition Date 2025-11-06

Release Date 2026-09-16

Last Version Date 2026-09-16

Entry Detail

PDB ID:

9Z3C

Keywords:

CHAPERONE

Title:

Human ClpP with drug

Biological Source:

Source Organism(s):

Homo sapiens (Taxon ID: 9606)

Expression System(s):

Escherichia coli

Method Details:

Experimental Method:

X-RAY DIFFRACTION

Resolution:

2.78 Å

R-Value Free:

0.24

R-Value Work:

0.18

R-Value Observed:

0.19

Space Group:

C 1 2 1

Download Validation Report

Macromolecular Entities

Polymer Type:polypeptide(L)
Molecule:ATP-dependent Clp protease pr
Chain IDs:A, B, C, D, E, F, G
Chain Length:221
Number of Molecules:7
Biological Source:Homo sapiens

Ligand Molecules

A1CZ5

GOL

Primary Citation

Dysregulation of Human ClpP Using Small Molecules with Piperazine-Based Scaffold for Diffuse Intrinsic Pontine Glioma Therapy Validated by Patient-Derived Tumor Organoids.

Miciaccia, M, Armenise, D, Baldelli, O.M, Liturri, A, Mammone, M, Graziano, G, Contino, M, Rizzo, F, Polosa, P.L, Bruni, F, Deligne, C, Broutier, L, Cavallaro, G, Fortuna, C.G, Tolomeo, A, Green, C, Bonifazi, A, Majaesic, E.M, Barghash, M.M, Josh Lee, N.P, Gratteri, C, Talarico, C, Filieri, S, Micalizzi, G, Donnarumma, D, Dugo, P, Mondello, L, Sardanelli, A.M, Houry, W.A, Nazarian, J, Ferorelli, S, Perrone, M.G, Scilimati, A.Show

J.Med.Chem. 69 18386 18413 (2026)

PMID: 42418817 DOI: 10.1021/acs.jmedchem.6c00777

Primary Citation of related structures

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