9Z0S image
Deposition Date 2025-11-03
Release Date 2026-10-14
Last Version Date 2026-10-21
Entry Detail
PDB ID:
9Z0S
Title:
Fab/epitope complex structure of anti-Tau monoclonal antibody PHF-1
Biological Source:
Source Organism(s):
Mus musculus (Taxon ID: 10090)
Homo sapiens (Taxon ID: 9606)
Expression System(s):
Method Details:
Experimental Method:
Resolution:
2.55 Å
R-Value Free:
0.24
R-Value Work:
0.18
R-Value Observed:
0.18
Space Group:
P 1 21 1
Macromolecular Entities
Structural Superimposition Protein Blast
Polymer Type:polypeptide(L)
Molecule:Heavy chain of Fab fragment o
Chain IDs:B (auth: H), E (auth: B), H (auth: E), K (auth: I), N (auth: M), Q
Chain Length:223
Number of Molecules:6
Biological Source:Mus musculus
Structural Superimposition Protein Blast
Polymer Type:polypeptide(L)
Molecule:Light chain of Fab fragment o
Chain IDs:A (auth: L), D (auth: A), G (auth: D), J (auth: G), M (auth: K), P (auth: O)
Chain Length:219
Number of Molecules:6
Biological Source:Mus musculus
Polymer Type:polypeptide(L)
Molecule:Microtubule-associated protei
Gene (Uniprot):MAPT
Chain IDs:C (auth: P), F (auth: C), I (auth: F), L (auth: J), O (auth: N), R
Chain Length:23
Number of Molecules:6
Biological Source:Homo sapiens
Modified Residue
Compound ID Chain ID Parent Comp ID Details 2D Image
SEP C, F, I, L, O, R SER modified residue
Primary Citation
Tau pSer396 and pSer404 Define Distinct Epitope Regions Linked to Different Antibody Functions.
Biorxiv ? ? ? (2026)
PMID: 42079100 DOI: 10.64898/2026.04.16.716390
Primary Citation of related structures
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