ISDA: 9Z03

Deposition Date 2025-10-30

Release Date 2026-08-19

Last Version Date 2026-08-19

Entry Detail

PDB ID:

9Z03

Keywords:

IMMUNE SYSTEM

Title:

Cryo-EM structure of VVD-908 NLRP3 complex

Biological Source:

Source Organism(s):

Homo sapiens (Taxon ID: 9606)

Expression System(s):

Homo sapiens

Method Details:

Experimental Method:

ELECTRON MICROSCOPY

Resolution:

3.03 Å

Aggregation State:

PARTICLE

Reconstruction Method:

SINGLE PARTICLE

Download Validation Report

Macromolecular Entities

Polymer Type:polypeptide(L)
Molecule:NACHT, LRR and PYD domains-co
Chain IDs:A
Chain Length:902
Number of Molecules:1
Biological Source:Homo sapiens

Ligand Molecules

A1CZP

ADP

Primary Citation

Chemoproteomic discovery of a brain-penetrant, covalent NLRP3 inhibitor that binds a novel allosteric pocket.

Rogness, D.C, Sievert, E.P, Vartabedian, V.F, Bernard, S.M, Aitchison, E, Tao, W, Lindvall, M, Qian, J, Eissler, C.L, Nordin, B.E, Horning, B.D, Kingston, C, Lamb, K.N, Bell, J.C, Lu, B, Pollock, J, Shi, J, Khattri, R, Weinstein, D.S, Patricelli, M.P, Cook, B.N, Simon, G.M.Show

Br.J.Pharmacol. ? ? ? (2026)

PMID: 42569816 DOI: 10.1111/bph.70626

Primary Citation of related structures

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