9YYU image
Deposition Date 2025-10-29
Release Date 2026-05-13
Last Version Date 2026-05-13
Entry Detail
PDB ID:
9YYU
Keywords:
VIRAL PROTEIN/IMMUNE SYSTEM
Title:
SARS-CoV-2 spike trimer in the early fusion intermediate conformation bound to the VN01H1 Fab (Fab local refinement)
Biological Source:
Source Organism(s):
Severe acute respiratory syndrome coronavirus 2 (Taxon ID: 2697049)
Homo sapiens (Taxon ID: 9606)
Expression System(s):
Homo sapiens
Method Details:
Experimental Method:
ELECTRON MICROSCOPY
Resolution:
3.30 Å
Aggregation State:
PARTICLE
Reconstruction Method:
SINGLE PARTICLE
9YYU validation report missing
Macromolecular Entities
Structures with similar UniProt ID
Protein Blast
Polymer Type:polypeptide(L)
Molecule:Spike glycoprotein
Gene (Uniprot):S
Mutagens:D614G variant, R682S, R683G
Chain IDs:A, D (auth: B), G (auth: C)
Chain Length:1281
Number of Molecules:3
Biological Source:Severe acute respiratory syndrome coronavirus 2
UniProt ID:P0DTC2 Pfam ID:PF16451, PF09408, PF19209, PF01601
Structures with similar UniProt ID
Protein Blast
Polymer Type:polypeptide(L)
Molecule:VN01H1 Fab heavy chain
Chain IDs:B (auth: H), E (auth: I), H (auth: J)
Chain Length:226
Number of Molecules:3
Biological Source:Homo sapiens
UniProt ID:9YYU
Structures with similar UniProt ID
Protein Blast
Polymer Type:polypeptide(L)
Molecule:VN01H1 Fab light chain
Chain IDs:C (auth: L), F (auth: M), I (auth: N)
Chain Length:215
Number of Molecules:3
Biological Source:Homo sapiens
UniProt ID:9YYU
Ligand Molecules
NAG
Primary Citation
TMPRSS2-mediated coronavirus spike activation and inhibition.
Nat.Struct.Mol.Biol. ? ? ? (2026)
PMID: 42050172 DOI: 10.1038/s41594-026-01801-y
Primary Citation of related structures
9YYU
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