9YWS image
Deposition Date 2025-10-25
Release Date 2026-07-22
Last Version Date 2026-07-22
Entry Detail
PDB ID:
9YWS
Keywords:
PROTEIN TRANSPORT
Title:
Human Sec61 complex bound to coibamide A
Biological Source:
Source Organism(s):
Homo sapiens (Taxon ID: 9606)
Leptolyngbya sp. (Taxon ID: 47254)
Expression System(s):
Spodoptera frugiperda
Method Details:
Experimental Method:
ELECTRON MICROSCOPY
Resolution:
3.10 Å
Aggregation State:
PARTICLE
Reconstruction Method:
SINGLE PARTICLE
9YWS validation report missing
Macromolecular Entities
Structures with similar UniProt ID
Structural Superimposition Protein Blast
Polymer Type:polypeptide(L)
Molecule:Protein transport protein Sec
Gene (Uniprot):SEC61A1
Chain IDs:C (auth: A)
Chain Length:476
Number of Molecules:1
Biological Source:Homo sapiens
UniProt ID:P61619 Pfam ID:PF10559, PF00344
Structures with similar UniProt ID
Structural Superimposition Protein Blast
Polymer Type:polypeptide(L)
Molecule:Protein transport protein Sec
Gene (Uniprot):SEC61G
Chain IDs:A (auth: B)
Chain Length:68
Number of Molecules:1
Biological Source:Homo sapiens
UniProt ID:P60059 Pfam ID:PF00584
Structures with similar UniProt ID
Structural Superimposition Protein Blast
Polymer Type:polypeptide(L)
Molecule:Protein transport protein Sec
Gene (Uniprot):SEC61B
Chain IDs:B (auth: C)
Chain Length:96
Number of Molecules:1
Biological Source:Homo sapiens
UniProt ID:P60468 Pfam ID:PF03911
Structural Superimposition Protein Blast
Polymer Type:polypeptide(L)
Molecule:Coibamide A
Chain IDs:D
Chain Length:11
Number of Molecules:1
Biological Source:Leptolyngbya sp.
Ligand Molecules
CLR
Primary Citation
Structure-based design of Sec61 translocon targeting prodrugs minimize off-target toxicity.
Cell Chem Biol 33 823 836.e21 (2026)
PMID: 42263680 DOI: 10.1016/j.chembiol.2026.05.006
Primary Citation of related structures
9YWS
Feedback Form
Name
Email
Institute
Feedback