ISDA: 9YVL

Deposition Date 2025-10-23

Release Date 2026-07-01

Last Version Date 2026-07-08

Entry Detail

PDB ID:

9YVL

Keywords:

TRANSPORT PROTEIN

Title:

Cryo-EM structure of the human TRPM4 channel in an open state bound to NC1 and PI(4,5)P2.

Biological Source:

Source Organism(s):

Homo sapiens (Taxon ID: 9606)

Expression System(s):

Homo sapiens

Method Details:

Experimental Method:

ELECTRON MICROSCOPY

Resolution:

2.78 Å

Aggregation State:

PARTICLE

Reconstruction Method:

SINGLE PARTICLE

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Macromolecular Entities

Structures with similar UniProt ID

Structural Superimposition Protein Blast

Polymer Type:polypeptide(L)
Molecule:Transient receptor potential
Gene (Uniprot):TRPM4
Chain IDs:A, B, C, D
Chain Length:1231
Number of Molecules:4
Biological Source:Homo sapiens

UniProt ID:Q8TD43 Pfam ID:PF18139, PF25508, PF00520

Ligand Molecules

A1CY8

PT5

Primary Citation

Structural mechanism of Necrocide 1 activation of human TRPM4 that triggers necrosis by sodium overload.

Teixeira-Duarte, C.M, Fu, W, Zeng, W, Wang, J, Jiang, X, Zhao, Z, Zhong, Q, Jiang, Y.Show

Nat Commun ? ? ? (2026)

PMID: 42342693 DOI: 10.1038/s41467-026-74814-2

Primary Citation of related structures

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