9YVK image
Deposition Date 2025-10-23
Release Date 2026-07-01
Last Version Date 2026-07-01
Entry Detail
PDB ID:
9YVK
Keywords:
TRANSPORT PROTEIN
Title:
Cryo-EM structure of the human TRPM4 channel bound to NC1 in the presence of EGTA.
Biological Source:
Source Organism(s):
Homo sapiens (Taxon ID: 9606)
Expression System(s):
Homo sapiens
Method Details:
Experimental Method:
ELECTRON MICROSCOPY
Resolution:
2.69 Å
Aggregation State:
PARTICLE
Reconstruction Method:
SINGLE PARTICLE
9YVK validation report missing
Macromolecular Entities
Structures with similar UniProt ID
Protein Blast
Polymer Type:polypeptide(L)
Molecule:Transient receptor potential
Gene (Uniprot):TRPM4
Chain IDs:A (auth: C), B (auth: A), C (auth: B), D
Chain Length:1231
Number of Molecules:4
Biological Source:Homo sapiens
UniProt ID:Q8TD43 Pfam ID:PF18139, PF25508, PF00520
Ligand Molecules
A1CY8
Primary Citation
Structural mechanism of Necrocide 1 activation of human TRPM4 that triggers necrosis by sodium overload
Nat Commun ? ? ? (2026)
DOI: 10.1038/s41467-026-74814-2
Primary Citation of related structures
9YVK
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