ISDA: 9YUZ

Deposition Date 2025-10-23

Release Date 2026-04-15

Last Version Date 2026-04-15

Entry Detail

PDB ID:

9YUZ

Keywords:

HYDROLASE

Title:

Structure of the human 20S proteasome in complex with a beta5-selective covalent syringolin analogue inhibitor.

Biological Source:

Source Organism(s):

Homo sapiens (Taxon ID: 9606)

Expression System(s):

Spodoptera frugiperda

Method Details:

Experimental Method:

ELECTRON MICROSCOPY

Resolution:

2.60 Å

Aggregation State:

PARTICLE

Reconstruction Method:

SINGLE PARTICLE

Download Validation Report

Macromolecular Entities

Structures with similar UniProt ID

Protein Blast

Polymer Type:polypeptide(L)
Molecule:Proteasome subunit alpha type
Gene (Uniprot):PSMA2
Chain IDs:A, O
Chain Length:264
Number of Molecules:2
Biological Source:Homo sapiens

UniProt ID:P25787 Pfam ID:PF10584, PF00227

Structures with similar UniProt ID

Protein Blast

Polymer Type:polypeptide(L)
Molecule:Proteasome subunit alpha type
Gene (Uniprot):PSMA4
Chain IDs:B, P
Chain Length:261
Number of Molecules:2
Biological Source:Homo sapiens

UniProt ID:P25789 Pfam ID:PF10584, PF00227 EC:3.4.25.1

Structures with similar UniProt ID

Protein Blast

Polymer Type:polypeptide(L)
Molecule:Proteasome subunit alpha type
Gene (Uniprot):PSMA7
Chain IDs:C, Q
Chain Length:248
Number of Molecules:2
Biological Source:Homo sapiens

UniProt ID:O14818 Pfam ID:PF10584, PF00227

Structures with similar UniProt ID

Protein Blast

Polymer Type:polypeptide(L)
Molecule:Proteasome subunit alpha type
Gene (Uniprot):PSMA5
Chain IDs:D, R
Chain Length:241
Number of Molecules:2
Biological Source:Homo sapiens

UniProt ID:P28066 Pfam ID:PF10584, PF00227

Structures with similar UniProt ID

Protein Blast

Polymer Type:polypeptide(L)
Molecule:Proteasome subunit alpha type
Gene (Uniprot):PSMA1
Chain IDs:E, S
Chain Length:263
Number of Molecules:2
Biological Source:Homo sapiens

UniProt ID:P25786 Pfam ID:PF10584, PF00227

Structures with similar UniProt ID

Protein Blast

Polymer Type:polypeptide(L)
Molecule:Proteasome subunit alpha type
Gene (Uniprot):PSMA3
Chain IDs:F, T
Chain Length:255
Number of Molecules:2
Biological Source:Homo sapiens

UniProt ID:P25788 Pfam ID:PF10584, PF00227

Structures with similar UniProt ID

Protein Blast

Polymer Type:polypeptide(L)
Molecule:Proteasome subunit alpha type
Gene (Uniprot):PSMA6
Chain IDs:G, U
Chain Length:246
Number of Molecules:2
Biological Source:Homo sapiens

UniProt ID:P60900 Pfam ID:PF10584, PF00227

Structures with similar UniProt ID

Protein Blast

Polymer Type:polypeptide(L)
Molecule:Proteasome subunit beta type-
Gene (Uniprot):PSMB7
Chain IDs:H, V
Chain Length:277
Number of Molecules:2
Biological Source:Homo sapiens

UniProt ID:Q99436 Pfam ID:PF00227, PF12465

Structures with similar UniProt ID

Protein Blast

Polymer Type:polypeptide(L)
Molecule:Proteasome subunit beta type-
Gene (Uniprot):PSMB3
Chain IDs:I, W
Chain Length:205
Number of Molecules:2
Biological Source:Homo sapiens

UniProt ID:P49720 Pfam ID:PF00227

Structures with similar UniProt ID

Protein Blast

Polymer Type:polypeptide(L)
Molecule:Proteasome subunit beta type-
Gene (Uniprot):PSMB2
Chain IDs:J, X
Chain Length:201
Number of Molecules:2
Biological Source:Homo sapiens

UniProt ID:P49721 Pfam ID:PF00227

Structures with similar UniProt ID

Protein Blast

Polymer Type:polypeptide(L)
Molecule:Proteasome subunit beta type-
Gene (Uniprot):PSMB5
Chain IDs:K, Y
Chain Length:263
Number of Molecules:2
Biological Source:Homo sapiens

UniProt ID:P28074 Pfam ID:PF00227

Structures with similar UniProt ID

Protein Blast

Polymer Type:polypeptide(L)
Molecule:Proteasome subunit beta type-
Gene (Uniprot):PSMB1
Chain IDs:L, Z
Chain Length:241
Number of Molecules:2
Biological Source:Homo sapiens

UniProt ID:P20618 Pfam ID:PF00227

Structures with similar UniProt ID

Protein Blast

Polymer Type:polypeptide(L)
Molecule:Proteasome subunit beta type-
Gene (Uniprot):PSMB4
Chain IDs:M, AA (auth: a)
Chain Length:264
Number of Molecules:2
Biological Source:Homo sapiens

UniProt ID:P28070 Pfam ID:PF00227

Structures with similar UniProt ID

Protein Blast

Polymer Type:polypeptide(L)
Molecule:Proteasome subunit beta type-
Gene (Uniprot):PSMB6
Chain IDs:N, BA (auth: b)
Chain Length:261
Number of Molecules:2
Biological Source:Homo sapiens

UniProt ID:P28072 Pfam ID:PF00227

Ligand Molecules

A1CY5

Primary Citation

An Optimized Route to the Syringolin Natural Products Enables Combinatorial Synthesis of Selective, Bioactive Inhibitors of the Plasmodium falciparum 20S Proteasome.

Gu, X, Fajtova, P, Yan, N.L, Saxena, A, Fei, F, Zhu, J, Tse, E, Melo, A, Yoo, E, Buchwald, N.H, Southworth, D.R, Bogyo, M, Derisi, J.L, Gestwicki, J.E, O'Donoghue, A.J, Sello, J.K.Show

J. Med. Chem. ? ? ? (2026)

PMID: 41921688 DOI: 10.1021/acs.jmedchem.5c03223

Primary Citation of related structures

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