ISDA: 9YTS

Deposition Date 2025-10-21

Release Date 2026-06-10

Last Version Date 2026-06-10

Entry Detail

PDB ID:

9YTS

Keywords:

VIRAL PROTEIN/IMMUNE SYSTEM

Title:

Cryo-EM structure of the parainfluenza virus hemagglutinin-neuraminidase protein in complex with the human antibodies 5217-2 and PIV3HN-09

Biological Source:

Source Organism(s):

Human respirovirus 3 (Taxon ID: 11216)
Homo sapiens (Taxon ID: 9606)

Expression System(s):

Homo sapiens

Method Details:

Experimental Method:

ELECTRON MICROSCOPY

Resolution:

3.29 Å

Aggregation State:

PARTICLE

Reconstruction Method:

SINGLE PARTICLE

Download Validation Report

Macromolecular Entities

Structures with similar UniProt ID

Protein Blast

Polymer Type:polypeptide(L)
Molecule:Hemagglutinin-neuraminidase
Gene (Uniprot):HN
Chain IDs:A, B (auth: F)
Chain Length:438
Number of Molecules:2
Biological Source:Human respirovirus 3

UniProt ID:Q81080

Protein Blast

Polymer Type:polypeptide(L)
Molecule:5217-2 Fab KC
Chain IDs:H (auth: B), J (auth: H)
Chain Length:107
Number of Molecules:2
Biological Source:Homo sapiens

Protein Blast

Polymer Type:polypeptide(L)
Molecule:5217-2 Fab HC
Chain IDs:G (auth: C), I (auth: G)
Chain Length:120
Number of Molecules:2
Biological Source:Homo sapiens

Protein Blast

Polymer Type:polypeptide(L)
Molecule:PIV3HN-09 Fab HC
Chain IDs:C (auth: D), E (auth: I)
Chain Length:123
Number of Molecules:2
Biological Source:Homo sapiens

Protein Blast

Polymer Type:polypeptide(L)
Molecule:PIV3HN-09 Fab KC
Chain IDs:D (auth: E), F (auth: J)
Chain Length:107
Number of Molecules:2
Biological Source:Homo sapiens

Ligand Molecules

Primary Citation

Structural Insights into HN-Targeted Monoclonal Antibodies against Human Parainfluenza Virus Type 3

McCaffrey, K.D, Mousa, J.J.Show

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Primary Citation of related structures

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