9YT9 image
Deposition Date 2025-10-20
Release Date 2026-07-15
Last Version Date 2026-07-15
Entry Detail
PDB ID:
9YT9
Keywords:
TRANSFERASE
Title:
A428D mutant of Bruton's tyrosine kinase
Biological Source:
Source Organism(s):
Homo sapiens (Taxon ID: 9606)
Expression System(s):
Spodoptera frugiperda
Method Details:
Experimental Method:
X-RAY DIFFRACTION
Resolution:
1.80 Å
R-Value Free:
0.23
R-Value Work:
0.20
R-Value Observed:
0.20
Space Group:
P 2 21 21
9YT9 validation report missing
Macromolecular Entities
Structures with similar UniProt ID
Structural Superimposition Protein Blast
Polymer Type:polypeptide(L)
Molecule:Tyrosine-protein kinase BTK
Gene (Uniprot):BTK
Mutagens:A428D
Chain IDs:A
Chain Length:270
Number of Molecules:1
Biological Source:Homo sapiens
UniProt ID:Q06187 Pfam ID:PF07714 EC:2.7.10.2
Ligand Molecules
EDO
Primary Citation
Molecular and Structural Basis of Pan-Resistance to BTK Targeting Therapies via BTK A428D Mutation
To Be Published ? ? ? (?)
Primary Citation of related structures
9YT9
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