ISDA: 9YSQ

Deposition Date 2025-10-19

Release Date 2026-04-08

Last Version Date 2026-04-08

Entry Detail

PDB ID:

9YSQ

Keywords:

SIGNALING PROTEIN

Title:

Structure of a human NUAK1-MARK3 kinase domain chimera in complex with inhibitor

Biological Source:

Source Organism(s):

Homo sapiens (Taxon ID: 9606)

Expression System(s):

Escherichia coli bl21(de3)

Method Details:

Experimental Method:

X-RAY DIFFRACTION

Resolution:

2.40 Å

R-Value Free:

0.24

R-Value Work:

0.19

R-Value Observed:

0.19

Space Group:

P 1 21 1

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Macromolecular Entities

Structures with similar UniProt ID

Protein Blast

Polymer Type:polypeptide(L)
Molecule:MAP/microtubule affinity-regu
Gene (Uniprot):MARK3
Mutagens:I62L, L72R, V116I, G137K, F141Y, A146E
Chain IDs:A, B
Chain Length:328
Number of Molecules:2
Biological Source:Homo sapiens

UniProt ID:P27448 Pfam ID:PF00069, PF00627

Ligand Molecules

A1CZY

Primary Citation

Structure of a human NUAK1-MARK3 kinase domain chimera in complex with inhibitor

Mao, D.Y.L, Chini, F.D, Sicheri, F.Show

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