9YSO image
Deposition Date 2025-10-19
Release Date 2026-06-10
Last Version Date 2026-06-10
Entry Detail
PDB ID:
9YSO
Keywords:
HYDROLASE/INHIBITOR
Title:
Human DCTPP1 bound to a Class II inhibitor
Biological Source:
Source Organism(s):
Homo sapiens (Taxon ID: 9606)
Expression System(s):
Escherichia coli
Method Details:
Experimental Method:
X-RAY DIFFRACTION
Resolution:
1.70 Å
R-Value Free:
0.21
R-Value Work:
0.17
R-Value Observed:
0.17
Space Group:
P 1
9YSO validation report missing
Macromolecular Entities
Structures with similar UniProt ID
Protein Blast
Polymer Type:polypeptide(L)
Molecule:dCTP pyrophosphatase 1
Gene (Uniprot):DCTPP1
Chain IDs:A, B, C, D, E, F, G, H
Chain Length:110
Number of Molecules:8
Biological Source:Homo sapiens
UniProt ID:Q9H773 Pfam ID:PF12643 EC:3.6.1.12
Ligand Molecules
A1C0D
MG
PRO
Primary Citation
Structural insights into novel DCTPP1 antagonists and their synergistic action with DNMT inhibitors
To Be Published ? ? ? (?)
Primary Citation of related structures
9YSO
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