ISDA: 9YQQ

Deposition Date 2025-10-15

Release Date 2026-06-10

Last Version Date 2026-07-29

Entry Detail

PDB ID:

9YQQ

Keywords:

LIPID TRANSPORT

Title:

Cryo-EM structure of the VPS13C C-terminal region

Biological Source:

Source Organism(s):

Homo sapiens (Taxon ID: 9606)

Expression System(s):

Homo sapiens

Method Details:

Experimental Method:

ELECTRON MICROSCOPY

Resolution:

3.80 Å

Aggregation State:

PARTICLE

Reconstruction Method:

SINGLE PARTICLE

Download Validation Report

Macromolecular Entities

Structures with similar UniProt ID

Structural Superimposition Protein Blast

Polymer Type:polypeptide(L)
Molecule:Intermembrane lipid transfer
Gene (Uniprot):VPS13C
Chain IDs:A
Chain Length:3777
Number of Molecules:1
Biological Source:Homo sapiens

UniProt ID:Q709C8 Pfam ID:PF12624, PF25033, PF25036, PF25037

Ligand Molecules

Primary Citation

Cryo-EM structure of soluble VPS13C suggests its regulation by a conformational switch and by calmodulin.

Li, D, Wang, X, Hao, H, Eden, J, Hu, B, Walsh, E.E, Parson, M.A.H, Hamill, S, Li, Y, Chen, G, Burke, J.E, De Camilli, P, Reinisch, K.M.Show

Mol.Cell 86 2843 ? (2026)

PMID: 42413490 DOI: 10.1016/j.molcel.2026.06.028

Primary Citation of related structures

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