ISDA: 9YQK

Deposition Date 2025-10-15

Release Date 2026-08-12

Last Version Date 2026-08-19

Entry Detail

PDB ID:

9YQK

Keywords:

PROTEIN BINDING

Title:

C-terminal LRRK2 bound to C12 DARPin

Biological Source:

Source Organism(s):

Homo sapiens (Taxon ID: 9606)
synthetic construct (Taxon ID: 32630)

Expression System(s):

Spodoptera frugiperda, Escherichia coli

Method Details:

Experimental Method:

ELECTRON MICROSCOPY

Resolution:

3.60 Å

Aggregation State:

PARTICLE

Reconstruction Method:

SINGLE PARTICLE

Download Validation Report

Macromolecular Entities

Structures with similar UniProt ID

Structural Superimposition Protein Blast

Polymer Type:polypeptide(L)
Molecule:Leucine-rich repeat serine/th
Gene (Uniprot):LRRK2
Chain IDs:A
Chain Length:0
Number of Molecules:1
Biological Source:Homo sapiens

UniProt ID:Q5S007 Pfam ID:PF23744, PF23745, PF13855, PF08477, PF16095, PF25497, PF00069, PF23748

Polymer Type:polypeptide(L)
Molecule:C12 DARPin
Chain IDs:B
Chain Length:0
Number of Molecules:1
Biological Source:synthetic construct

Ligand Molecules

Primary Citation

The structural basis for LRRK2's activation and autoinhibition.

Villagran Suarez, A, Hatch, K.S, Bodrug, T, Gai, W, Surridge, K.J, Moussikhina, E, Nguyen, K.H.V, Sanz-Murillo, M, Callahan, R, Xiong, E, Ramos, D, Zhu, L, Dederer, V, Mathea, S, Iwasa, J, Knapp, S, Shokat, K.M, Reck-Peterson, S.L, Leschziner, A.E.Show

Cell ? ? ? (2026)

PMID: 42575089 DOI: 10.1016/j.cell.2026.07.027

Primary Citation of related structures

Feedback Form