ISDA: 9YQ6

Deposition Date 2025-10-15

Release Date 2026-06-10

Last Version Date 2026-06-10

Entry Detail

PDB ID:

9YQ6

Keywords:

ANTIVIRAL PROTEIN

Title:

Cryo-EM structure of the parainfluenza virus hemagglutinin-neuraminidase protein in complex with the human antibodies PIV3HN-09 and PIV3HN-13

Biological Source:

Source Organism(s):

Human respirovirus 3 (Taxon ID: 11216)
Homo sapiens (Taxon ID: 9606)

Expression System(s):

Homo sapiens

Method Details:

Experimental Method:

ELECTRON MICROSCOPY

Resolution:

2.95 Å

Aggregation State:

PARTICLE

Reconstruction Method:

SINGLE PARTICLE

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Macromolecular Entities

Structures with similar UniProt ID

Protein Blast

Polymer Type:polypeptide(L)
Molecule:Hemagglutinin-neuraminidase
Gene (Uniprot):HN
Chain IDs:A, B (auth: F)
Chain Length:438
Number of Molecules:2
Biological Source:Human respirovirus 3

UniProt ID:Q81080

Protein Blast

Polymer Type:polypeptide(L)
Molecule:PIV3HN-13 Fab Heavy Chain
Chain IDs:C (auth: B), E (auth: G)
Chain Length:121
Number of Molecules:2
Biological Source:Homo sapiens

Protein Blast

Polymer Type:polypeptide(L)
Molecule:PIV3HN-13 Fab Kappa Chain
Chain IDs:D (auth: C), F (auth: H)
Chain Length:111
Number of Molecules:2
Biological Source:Homo sapiens

Protein Blast

Polymer Type:polypeptide(L)
Molecule:PIV3HN-09 Fab Heavy Chain
Chain IDs:G (auth: D), I
Chain Length:123
Number of Molecules:2
Biological Source:Homo sapiens

Protein Blast

Polymer Type:polypeptide(L)
Molecule:PIV3HN-09 Fab Kappa Chain
Chain IDs:H (auth: E), J
Chain Length:107
Number of Molecules:2
Biological Source:Homo sapiens

Ligand Molecules

Primary Citation

Structural Insights into HN-Targeted Monoclonal Antibodies against Human Parainfluenza Virus Type 3

McCaffrey, K.D, Mousa, J.J.Show

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Primary Citation of related structures

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