ISDA: 9YOI

Deposition Date 2025-10-13

Release Date 2026-08-26

Last Version Date 2026-08-26

Entry Detail

PDB ID:

9YOI

Keywords:

VIRAL PROTEIN

Title:

Crystal structure of H3 hemagglutinin with HA2 N95L mutation from the influenza virus A/Hong Kong/1/1968 (H3N2)

Biological Source:

Source Organism(s):

Influenza A virus (Taxon ID: 11320)

Expression System(s):

Trichoplusia ni

Method Details:

Experimental Method:

X-RAY DIFFRACTION

Resolution:

2.29 Å

R-Value Free:

0.26

R-Value Work:

0.22

R-Value Observed:

0.22

Space Group:

P 21 21 21

Download Validation Report

Macromolecular Entities

Polymer Type:polypeptide(L)
Molecule:Hemagglutinin HA1
Chain IDs:A (auth: C), C (auth: A), E
Chain Length:322
Number of Molecules:3
Biological Source:Influenza A virus

Polymer Type:polypeptide(L)
Molecule:Hemagglutinin HA2
Mutagens:N95L
Chain IDs:B (auth: D), D (auth: B), F
Chain Length:196
Number of Molecules:3
Biological Source:Influenza A virus

Ligand Molecules

NAG

Primary Citation

Single-component self-assembling protein nanoparticles displaying stabilized prefusion-closed hemagglutinin trimers for influenza vaccine development

Zhang, Y.N, Zhu, X, Braz Gomes, K, Lee, Y.Z, DesRoberts, C, He, L, Wilson, I.A, Zhu, J.Show

Nat Commun ? ? ? (2026)

DOI: 10.1038/s41467-026-76731-w

Primary Citation of related structures

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