ISDA: 9YMK

Deposition Date 2025-10-10

Release Date 2026-07-08

Last Version Date 2026-07-08

Entry Detail

PDB ID:

9YMK

Keywords:

VIRAL PROTEIN/IMMUNE SYSTEM

Title:

RVz20_wk72_08 Fab in complex with BG505 MD39 SOSIP and RM20A3 Fab

Biological Source:

Source Organism(s):

Macaca mulatta (Taxon ID: 9544)
Human immunodeficiency virus 1 (Taxon ID: 11676)

Expression System(s):

Homo sapiens

Method Details:

Experimental Method:

ELECTRON MICROSCOPY

Resolution:

2.70 Å

Aggregation State:

PARTICLE

Reconstruction Method:

SINGLE PARTICLE

Download Validation Report

Macromolecular Entities

Structures with similar UniProt ID

Protein Blast

Polymer Type:polypeptide(L)
Molecule:BG505 MD39 SOSIP gp120
Gene (Uniprot):env
Chain IDs:C (auth: A), I (auth: C), O (auth: E)
Chain Length:513
Number of Molecules:3
Biological Source:Human immunodeficiency virus 1

UniProt ID:Q2N0S6

Structures with similar UniProt ID

Protein Blast

Polymer Type:polypeptide(L)
Molecule:BG505 MD39 SOSIP gp41
Gene (Uniprot):env
Chain IDs:D (auth: B), J (auth: D), P (auth: F)
Chain Length:153
Number of Molecules:3
Biological Source:Human immunodeficiency virus 1

UniProt ID:Q2N0S6

Protein Blast

Polymer Type:polypeptide(L)
Molecule:RM20A3 Fab heavy chain
Chain IDs:A (auth: G), G (auth: J), M (auth: O)
Chain Length:229
Number of Molecules:3
Biological Source:Macaca mulatta

Protein Blast

Polymer Type:polypeptide(L)
Molecule:RVz20_wk72_08 Fab heavy chain
Chain IDs:E (auth: H), K, Q (auth: P)
Chain Length:230
Number of Molecules:3
Biological Source:Macaca mulatta

Protein Blast

Polymer Type:polypeptide(L)
Molecule:RM20A3 light chain
Chain IDs:B (auth: I), H (auth: M), N (auth: Q)
Chain Length:215
Number of Molecules:3
Biological Source:Macaca mulatta

Protein Blast

Polymer Type:polypeptide(L)
Molecule:RVz20_wk72_08 light chain
Chain IDs:F (auth: L), L (auth: N), R
Chain Length:217
Number of Molecules:3
Biological Source:Macaca mulatta

Ligand Molecules

NAG

Primary Citation

Vaccination elicits HIV broadly neutralizing antibodies in primates

Steichen, J.M, Madden, P.J, Flynn, C.T, Phulera, S, Shil, M, Kalyuzhniy, O, Liguori, A, Kifude, C, Sewall, L.M, Cottrell, C.A, Ma, K.M, Baboo, S, Diedrich, J.K, McKenney, K, deCamp, A.C, Carnathan, D.G, Phung, I, Ramezani-Rad, P, Marina-Zarate, E, Freeman, B, Xie, Z, Lee, J.H, Sincomb, T, Phelps, N, Lu, D, Goodwin, D, Tingle, R, Adachi, Y, Alavi, N, Tran, J, Tran, A.S, Nascimento, A, Sovie, C, Bader, D.L.V, Voic, H, Zhou, X, Pixton, G, Walsh, A, Melo, M.B, Schiffner, T, Batista, F.D, Burton, D.R, Irvine, D.J, Paulson, J.C, Yates, J.R, Ozorowski, G, Ward, A.B, Silvestri, G, Crotty, S, Schief, W.R.Show

Nature ? ? ? (2026)

DOI: 10.1038/s41586-026-10837-5

Primary Citation of related structures

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