ISDA: 9YLY

Deposition Date 2025-10-09

Release Date 2026-06-03

Last Version Date 2026-06-03

Entry Detail

PDB ID:

9YLY

Keywords:

TRANSCRIPTION/DNA

Title:

MLL4FC bound to a nucleosome with p53 RE

Biological Source:

Source Organism(s):

Homo sapiens (Taxon ID: 9606)
synthetic construct (Taxon ID: 32630)

Expression System(s):

Escherichia coli, Spodoptera frugiperda

Method Details:

Experimental Method:

ELECTRON MICROSCOPY

Resolution:

3.77 Å

Aggregation State:

PARTICLE

Reconstruction Method:

SINGLE PARTICLE

Download Validation Report

Macromolecular Entities

Structures with similar UniProt ID

Protein Blast

Polymer Type:polypeptide(L)
Molecule:Histone H3.1
Gene (Uniprot):H3C1, H3C2, H3C3, H3C4, H3C6, H3C7, H3C8, H3C10, H3C11, H3C12
Chain IDs:A, E
Chain Length:135
Number of Molecules:2
Biological Source:Homo sapiens

UniProt ID:P68431 Pfam ID:PF00125

Structures with similar UniProt ID

Protein Blast

Polymer Type:polypeptide(L)
Molecule:Histone H4
Gene (Uniprot):H4C1, H4C2, H4C3, H4C4, H4C5, H4C6, H4C8, H4C9, H4C11, H4C12, H4C13, H4C14, H4C15, H4C16
Chain IDs:B, F
Chain Length:102
Number of Molecules:2
Biological Source:Homo sapiens

UniProt ID:P62805 Pfam ID:PF15511

Structures with similar UniProt ID

Protein Blast

Polymer Type:polypeptide(L)
Molecule:Histone H2A type 1-B/E
Gene (Uniprot):H2AC4, H2AC8
Chain IDs:C, G
Chain Length:129
Number of Molecules:2
Biological Source:Homo sapiens

UniProt ID:P04908 Pfam ID:PF00125, PF16211

Structures with similar UniProt ID

Protein Blast

Polymer Type:polypeptide(L)
Molecule:Histone H2B type 2-E
Gene (Uniprot):H2BC21
Chain IDs:D, H
Chain Length:125
Number of Molecules:2
Biological Source:Homo sapiens

UniProt ID:Q16778 Pfam ID:PF00125

Polymer Type:polydeoxyribonucleotide
Molecule:DNA (165-MER)
Chain IDs:O (auth: I)
Chain Length:167
Number of Molecules:1
Biological Source:synthetic construct

Polymer Type:polydeoxyribonucleotide
Molecule:DNA (165-MER)
Chain IDs:P (auth: J)
Chain Length:167
Number of Molecules:1
Biological Source:synthetic construct

Protein Blast

Polymer Type:polypeptide(L)
Molecule:[histone H3]-lysine(4) N-meth
Gene (Uniprot):KMT2D, KMT2D
Chain IDs:K
Chain Length:1256
Number of Molecules:1
Biological Source:Homo sapiens

UniProt ID:A0A6P6IDI8,O14686 Pfam ID:PF13832, PF05964, PF05965, PF00856 EC:2.1.1.364

Structures with similar UniProt ID

Protein Blast

Polymer Type:polypeptide(L)
Molecule:Retinoblastoma-binding protei
Gene (Uniprot):RBBP5
Chain IDs:J (auth: N)
Chain Length:538
Number of Molecules:1
Biological Source:Homo sapiens

UniProt ID:Q15291 Pfam ID:PF00400

Structures with similar UniProt ID

Protein Blast

Polymer Type:polypeptide(L)
Molecule:Protein dpy-30 homolog
Gene (Uniprot):DPY30
Chain IDs:M (auth: P), N (auth: Q)
Chain Length:99
Number of Molecules:2
Biological Source:Homo sapiens

UniProt ID:Q9C005 Pfam ID:PF05186

Structures with similar UniProt ID

Protein Blast

Polymer Type:polypeptide(L)
Molecule:WD repeat-containing protein
Gene (Uniprot):WDR5
Chain IDs:I (auth: R)
Chain Length:334
Number of Molecules:1
Biological Source:Homo sapiens

UniProt ID:P61964 Pfam ID:PF25175

Structures with similar UniProt ID

Protein Blast

Polymer Type:polypeptide(L)
Molecule:Set1/Ash2 histone methyltrans
Gene (Uniprot):ASH2L
Chain IDs:L (auth: T)
Chain Length:628
Number of Molecules:1
Biological Source:Homo sapiens

UniProt ID:Q9UBL3 Pfam ID:PF21257, PF21198, PF00622

Ligand Molecules