9YKV image
Deposition Date 2025-10-07
Release Date 2026-08-12
Last Version Date 2026-08-12
Entry Detail
PDB ID:
9YKV
Keywords:
TRANSFERASE/Ligase
Title:
Cryo-EM structure of double-loaded human UBA6-UBE2Z-FAT10(t)/FAT10(a) thioester mimetic complex.
Biological Source:
Source Organism(s):
Homo sapiens (Taxon ID: 9606)
Expression System(s):
Trichoplusia ni, Escherichia coli
Method Details:
Experimental Method:
ELECTRON MICROSCOPY
Resolution:
2.73 Å
Aggregation State:
PARTICLE
Reconstruction Method:
SINGLE PARTICLE
9YKV validation report missing
Macromolecular Entities
Polymer Type:polypeptide(L)
Molecule:Ubiquitin-like modifier-activ
Chain IDs:A
Chain Length:1016
Number of Molecules:1
Biological Source:Homo sapiens
Polymer Type:polypeptide(L)
Molecule:Ubiquitin-conjugating enzyme
Mutagens:C100S, K130R, K166R, Y182K, K186R, C261S, C263S
Chain IDs:B
Chain Length:262
Number of Molecules:1
Biological Source:Homo sapiens
Polymer Type:polypeptide(L)
Molecule:Ubiquitin D
Mutagens:C7T, C9T,C134L,C160S,C162S
Chain IDs:C, D
Chain Length:165
Number of Molecules:2
Biological Source:Homo sapiens
Ligand Molecules
AMP
IHP
POP
Primary Citation
Cryo-EM structures of UBA6 reveal mechanisms of E1-E2 specificity and dual FAT10/ubiquitin thioester transfer.
Nat Commun 17 ? ? (2026)
PMID: 41764162 DOI: 10.1038/s41467-026-69882-3
Primary Citation of related structures
9YKV
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