ISDA: 9YKR

Deposition Date 2025-10-07

Release Date 2026-05-13

Last Version Date 2026-05-13

Entry Detail

PDB ID:

9YKR

Keywords:

TRANSFERASE

Title:

Crystal structure of the GLP (EHMT1) SET domain in complex with SAM and TNG917

Biological Source:

Source Organism(s):

Homo sapiens (Taxon ID: 9606)

Expression System(s):

Escherichia coli

Method Details:

Experimental Method:

X-RAY DIFFRACTION

Resolution:

1.38 Å

R-Value Free:

0.15

R-Value Work:

0.12

R-Value Observed:

0.12

Space Group:

P 21 21 21

Download Validation Report

Macromolecular Entities

Structures with similar UniProt ID

Protein Blast

Polymer Type:polypeptide(L)
Molecule:Histone-lysine N-methyltransf
Gene (Uniprot):EHMT1
Chain IDs:A, B
Chain Length:262
Number of Molecules:2
Biological Source:Homo sapiens

UniProt ID:Q9H9B1 Pfam ID:PF05033, PF00856 EC:2.1.1.367

Ligand Molecules

A1CXM

EDO

PEG

SAM

SO4

Primary Citation

TNG917 is a Potent and Selective Inhibitor of Histone Lysine Methyltransferases EHMT1/2 that Enhances Anti-Tumor Immunity and Immunotherapy Efficacy

Lu, A, Haines, B.B, Zhang, W, Zhang, M, Whittington, D.A, Ji, L, Teng, T, Ferdinez, M.L.D, Yu, Y, Zhang, H, Gu, L, Tsai, A.W, Sudsakorn, S, Mallender, W.D, Williams, B, Come, J.H, Throner, S, Vacca, J, Huang, A, Min, C, Maxwell, J.P, Andersen, J.N, Chen, Y.P.Show

Cancer Res. ? ? ? (2026)

Primary Citation of related structures

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