9YKI image
Deposition Date 2025-10-07
Release Date 2026-03-25
Last Version Date 2026-03-25
Entry Detail
PDB ID:
9YKI
Keywords:
TRANSFERASE
Title:
Crystal structure of human PIM1 kinase bound with CSH-4044 inhibitor
Biological Source:
Source Organism(s):
Homo sapiens (Taxon ID: 9606)
Expression System(s):
Escherichia coli
Method Details:
Experimental Method:
X-RAY DIFFRACTION
Resolution:
1.95 Å
R-Value Free:
0.19
R-Value Work:
0.16
R-Value Observed:
0.16
Space Group:
P 65
9YKI validation report
Macromolecular Entities
Structures with similar UniProt ID
Protein Blast
Polymer Type:polypeptide(L)
Molecule:Serine/threonine-protein kina
Gene (Uniprot):PIM1
Chain IDs:A
Chain Length:313
Number of Molecules:1
Biological Source:Homo sapiens
UniProt ID:P11309 Pfam ID:PF00069 EC:2.7.11.1
Modified Residue
Compound ID Chain ID Parent Comp ID Details 2D Image
SEP A SER modified residue
Ligand Molecules
A1CXP
GOL
MG
Primary Citation
Identification and Validation of an Inhibitor of the Protein Kinases PIM and DYRK.
J.Med.Chem. ? ? ? (2026)
PMID: 41849779 DOI: 10.1021/acs.jmedchem.5c03226
Primary Citation of related structures
9YKI
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