ISDA: 9YCD

Deposition Date 2025-09-18

Release Date 2026-08-19

Last Version Date 2026-08-19

Entry Detail

PDB ID:

9YCD

Keywords:

HYDROLASE

Title:

Leucine Rich Repeat Kinase 2 R1441C mutant (active)

Biological Source:

Source Organism(s):

Homo sapiens (Taxon ID: 9606)

Expression System(s):

Spodoptera frugiperda

Method Details:

Experimental Method:

ELECTRON MICROSCOPY

Resolution:

3.63 Å

Aggregation State:

PARTICLE

Reconstruction Method:

SINGLE PARTICLE

Download Validation Report

Macromolecular Entities

Polymer Type:polypeptide(L)
Molecule:Leucine-rich repeat serine/th
Mutagens:R1441C
Chain IDs:A
Chain Length:2527
Number of Molecules:1
Biological Source:Homo sapiens

Ligand Molecules

A1N

Primary Citation

The structural basis for LRRK2's activation and autoinhibition

Villagran Suarez, A, Hatch, K.S, Bodrug, T, Gai, W, Surridge, K.J, Moussikhina, E, Nguyen, K.H, Sanz-Murillo, M, Callahan, R, Xiong, E, Ramos, D, Zhu, L, Dederer, V, Mathea, S, Iwasa, J, Knapp, S, Shokat, K.M, Reck-Peterson, S.L, Leschziner, A.E.Show

Cell(Cambridge,Mass.) ? ? ? (2026)

DOI: 10.1016/j.cell.2026.07.027

Primary Citation of related structures

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