ISDA: 9YC8

Deposition Date 2025-09-18

Release Date 2026-08-19

Last Version Date 2026-08-19

Entry Detail

PDB ID:

9YC8

Keywords:

HYDROLASE

Title:

Leucine Rich Repeat Kinase 2 activate state (Apo ROC state 1)

Biological Source:

Source Organism(s):

Homo sapiens (Taxon ID: 9606)

Expression System(s):

Spodoptera frugiperda

Method Details:

Experimental Method:

ELECTRON MICROSCOPY

Resolution:

4.02 Å

Aggregation State:

PARTICLE

Reconstruction Method:

SINGLE PARTICLE

Download Validation Report

Macromolecular Entities

Polymer Type:polypeptide(L)
Molecule:Leucine-rich repeat serine/th
Chain IDs:A (auth: B)
Chain Length:2527
Number of Molecules:1
Biological Source:Homo sapiens

Ligand Molecules

Primary Citation

The structural basis for LRRK2's activation and autoinhibition

Villagran Suarez, A, Hatch, K.S, Bodrug, T, Gai, W, Surridge, K.J, Moussikhina, E, Nguyen, K.H, Sanz-Murillo, M, Callahan, R, Xiong, E, Ramos, D, Zhu, L, Dederer, V, Mathea, S, Iwasa, J, Knapp, S, Shokat, K.M, Reck-Peterson, S.L, Leschziner, A.E.Show

Cell(Cambridge,Mass.) ? ? ? (2026)

DOI: 10.1016/j.cell.2026.07.027

Primary Citation of related structures

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