9YAI image
Deposition Date 2025-09-16
Release Date 2026-04-22
Last Version Date 2026-04-22
Entry Detail
PDB ID:
9YAI
Keywords:
MOTOR PROTEIN
Title:
KIF1A R350W bound to microtubules in two-heads-bound state with AMP-PNP
Biological Source:
Source Organism(s):
Homo sapiens (Taxon ID: 9606)
Sus scrofa (Taxon ID: 9823)
Expression System(s):
Escherichia coli bl21(de3)
Method Details:
Experimental Method:
ELECTRON MICROSCOPY
Resolution:
3.12 Å
Aggregation State:
FILAMENT
Reconstruction Method:
HELICAL
9YAI validation report missing
Macromolecular Entities
Structures with similar UniProt ID
Protein Blast
Polymer Type:polypeptide(L)
Molecule:Tubulin alpha-1B chain
Gene (Uniprot):TUBA1B
Chain IDs:C (auth: A), E
Chain Length:451
Number of Molecules:2
Biological Source:Sus scrofa
UniProt ID:Q2XVP4 Pfam ID:PF00091, PF03953
Structures with similar UniProt ID
Protein Blast
Polymer Type:polypeptide(L)
Molecule:Tubulin beta-2B chain
Chain IDs:D (auth: B), F (auth: I)
Chain Length:445
Number of Molecules:2
Biological Source:Sus scrofa
UniProt ID:A0A287AGU7
Structures with similar UniProt ID
Protein Blast
Polymer Type:polypeptide(L)
Molecule:Kinesin-like protein KIF1A
Gene (Uniprot):KIF1A
Mutagens:R350W
Chain IDs:A (auth: K), B (auth: N)
Chain Length:438
Number of Molecules:2
Biological Source:Homo sapiens
UniProt ID:Q12756 Pfam ID:PF00225 EC:5.6.1.3
Ligand Molecules
ANP
GDP
GTP
MG
TA1
Primary Citation
Pathogenic KIF1A R350 mutations disrupt a conserved and conformation-dependent kinesin-tubulin salt bridge.
Nat Commun ? ? ? (2026)
PMID: 41912506 DOI: 10.1038/s41467-026-71026-6
Primary Citation of related structures
9YAI
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