ISDA: 9Y7R

Deposition Date 2025-09-11

Release Date 2026-07-22

Last Version Date 2026-07-22

Entry Detail

PDB ID:

9Y7R

Keywords:

OXIDOREDUCTASE

Title:

Crystal structure of Candida auris dihydrofolate reductase in complex with inhibitor 1283 and NADPH

Biological Source:

Source Organism(s):

Candidozyma auris (Taxon ID: 498019)

Expression System(s):

Escherichia coli

Method Details:

Experimental Method:

X-RAY DIFFRACTION

Resolution:

2.13 Å

R-Value Free:

0.23

R-Value Work:

0.18

R-Value Observed:

0.18

Space Group:

P 21 21 21

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Macromolecular Entities

Structures with similar UniProt ID

Structural Superimposition Protein Blast

Polymer Type:polypeptide(L)
Molecule:Dihydrofolate reductase
Gene (Uniprot):QG37_02791
Chain IDs:A (auth: B), B (auth: A)
Chain Length:208
Number of Molecules:2
Biological Source:Candidozyma auris

UniProt ID:A0A0L0P1H8 EC:1.5.1.3

Ligand Molecules

A1CTB

NDP

Primary Citation

Structural and biological evaluation of non-classical antifolates as antifungal drug candidates targeting Candia auris dihydrofolate reductase.

Erlandsen, H, Krucinska, J, Wright, D.Show

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Primary Citation of related structures

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