ISDA: 9Y77

Deposition Date 2025-09-09

Release Date 2026-09-30

Last Version Date 2026-09-30

Entry Detail

PDB ID:

9Y77

Keywords:

TRANSCRIPTION, TRANSFERASE/DNA/RNA/INHIBITOR

Title:

Cryo-EM structure of Mycobacterium tuberculosis transcription initiation complex in complex with UMN141

Biological Source:

Source Organism(s):

Mycobacterium tuberculosis H37Rv (Taxon ID: 83332)

Expression System(s):

Escherichia coli bl21(de3)

Method Details:

Experimental Method:

ELECTRON MICROSCOPY

Resolution:

2.58 Å

Aggregation State:

PARTICLE

Reconstruction Method:

SINGLE PARTICLE

Download Validation Report

Macromolecular Entities

Structures with similar UniProt ID

Structural Superimposition Protein Blast

Polymer Type:polypeptide(L)
Molecule:DNA-directed RNA polymerase s
Gene (Uniprot):rpoA
Chain IDs:A, B
Chain Length:0
Number of Molecules:2
Biological Source:Mycobacterium tuberculosis H37Rv

UniProt ID:P9WGZ1 Pfam ID:PF01193, PF01000, PF03118 EC:2.7.7.6

Structures with similar UniProt ID

Structural Superimposition Protein Blast

Polymer Type:polypeptide(L)
Molecule:DNA-directed RNA polymerase s
Gene (Uniprot):rpoB
Chain IDs:C
Chain Length:0
Number of Molecules:1
Biological Source:Mycobacterium tuberculosis H37Rv

UniProt ID:P0A681 Pfam ID:PF04563, PF04561, PF04565, PF10385, PF00562, PF04560 EC:2.7.7.6

Structures with similar UniProt ID

Structural Superimposition Protein Blast

Polymer Type:polypeptide(L)
Molecule:DNA-directed RNA polymerase s
Gene (Uniprot):rpoC
Chain IDs:D
Chain Length:0
Number of Molecules:1
Biological Source:Mycobacterium tuberculosis H37Rv

UniProt ID:P9WGY7 Pfam ID:PF04997, PF00623, PF04983, PF05000, PF04998 EC:2.7.7.6

Structures with similar UniProt ID

Structural Superimposition Protein Blast

Polymer Type:polypeptide(L)
Molecule:DNA-directed RNA polymerase s
Gene (Uniprot):rpoZ
Chain IDs:E
Chain Length:0
Number of Molecules:1
Biological Source:Mycobacterium tuberculosis H37Rv

UniProt ID:P9WGY5 Pfam ID:PF01192 EC:2.7.7.6

Structures with similar UniProt ID

Structural Superimposition Protein Blast

Polymer Type:polypeptide(L)
Molecule:RNA polymerase sigma factor S
Gene (Uniprot):sigA
Chain IDs:F
Chain Length:0
Number of Molecules:1
Biological Source:Mycobacterium tuberculosis H37Rv

UniProt ID:P9WGI1 Pfam ID:PF00140, PF04542, PF04539, PF04545 EC:2.7.7.6

Polymer Type:polydeoxyribonucleotide
Molecule:DNA (53-MER)
Chain IDs:G
Chain Length:0
Number of Molecules:1
Biological Source:Mycobacterium tuberculosis H37Rv

Polymer Type:polydeoxyribonucleotide
Molecule:DNA (53-MER)
Chain IDs:H
Chain Length:0
Number of Molecules:1
Biological Source:Mycobacterium tuberculosis H37Rv

Ligand Molecules