ISDA: 9Y61

Deposition Date 2025-09-06

Release Date 2026-07-15

Last Version Date 2026-07-15

Entry Detail

PDB ID:

9Y61

Keywords:

LIGASE

Title:

Cryo-EM structure of ternary complex NSD2-PWWP1:CRBN:DDB1 in complex with NSD2-LDD, an LDD degrader

Biological Source:

Source Organism(s):

Homo sapiens (Taxon ID: 9606)

Expression System(s):

Escherichia coli bl21(de3), Spodoptera frugiperda

Method Details:

Experimental Method:

ELECTRON MICROSCOPY

Resolution:

3.10 Å

Aggregation State:

PARTICLE

Reconstruction Method:

SINGLE PARTICLE

Download Validation Report

Macromolecular Entities

Structures with similar UniProt ID

Structural Superimposition Protein Blast

Polymer Type:polypeptide(L)
Molecule:Histone-lysine N-methyltransf
Gene (Uniprot):NSD2
Chain IDs:A
Chain Length:174
Number of Molecules:1
Biological Source:Homo sapiens

UniProt ID:O96028 Pfam ID:PF00855 EC:2.1.1.356

Structures with similar UniProt ID

Structural Superimposition Protein Blast

Polymer Type:polypeptide(L)
Molecule:Protein cereblon
Gene (Uniprot):CRBN
Chain IDs:B
Chain Length:467
Number of Molecules:1
Biological Source:Homo sapiens

UniProt ID:Q96SW2 Pfam ID:PF02190, PF03226

Ligand Molecules