ISDA: 9Y5X

Deposition Date 2025-09-05

Release Date 2026-01-07

Last Version Date 2026-07-22

Entry Detail

PDB ID:

9Y5X

Keywords:

PROTEIN BINDING

Title:

Crystal structure of shorter construct of SHP2 unbound N-SH2 domain

Biological Source:

Source Organism(s):

Homo sapiens (Taxon ID: 9606)

Expression System(s):

Escherichia coli bl21(de3)

Method Details:

Experimental Method:

X-RAY DIFFRACTION

Resolution:

1.80 Å

R-Value Free:

0.25

R-Value Work:

0.21

R-Value Observed:

0.21

Space Group:

P 43 21 2

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Macromolecular Entities

Structures with similar UniProt ID

Structural Superimposition Protein Blast

Polymer Type:polypeptide(L)
Molecule:Isoform 1 of Tyrosine-protein
Gene (Uniprot):PTPN11
Chain IDs:A
Chain Length:104
Number of Molecules:1
Biological Source:Homo sapiens

UniProt ID:Q06124 Pfam ID:PF00017 EC:3.1.3.48

Ligand Molecules

GOL

MES

SO4

Primary Citation

Phosphatase SHP2 pathogenic mutations enhance activity by altering conformational sampling.

Glaser, A.W, Padua, R.A.P, Ojoawo, A.M, Sullivan, C, Kern, D.Show

Proc.Natl.Acad.Sci.USA 123 e2513851123 e2513851123 (2026)

PMID: 41528873 DOI: 10.1073/pnas.2513851123

Primary Citation of related structures

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