ISDA: 9Y5U

Deposition Date 2025-09-05

Release Date 2026-07-08

Last Version Date 2026-07-08

Entry Detail

PDB ID:

9Y5U

Keywords:

TRANSLATION

Title:

eIF2B lacking the latch helix bound to ISRACT-02 (Inactive state)

Biological Source:

Source Organism(s):

Homo sapiens (Taxon ID: 9606)

Expression System(s):

Escherichia coli

Method Details:

Experimental Method:

ELECTRON MICROSCOPY

Resolution:

2.90 Å

Aggregation State:

PARTICLE

Reconstruction Method:

SINGLE PARTICLE

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Macromolecular Entities

Structures with similar UniProt ID

Protein Blast

Polymer Type:polypeptide(L)
Molecule:Translation initiation factor
Gene (Uniprot):EIF2B5
Chain IDs:A, B
Chain Length:721
Number of Molecules:2
Biological Source:Homo sapiens

UniProt ID:Q13144 Pfam ID:PF02020

Structures with similar UniProt ID

Protein Blast

Polymer Type:polypeptide(L)
Molecule:Translation initiation factor
Gene (Uniprot):EIF2B2
Chain IDs:C, D
Chain Length:355
Number of Molecules:2
Biological Source:Homo sapiens

UniProt ID:P49770 Pfam ID:PF01008

Structures with similar UniProt ID

Protein Blast

Polymer Type:polypeptide(L)
Molecule:Translation initiation factor
Gene (Uniprot):EIF2B4
Chain IDs:E, F
Chain Length:523
Number of Molecules:2
Biological Source:Homo sapiens

UniProt ID:Q9UI10 Pfam ID:PF01008

Structures with similar UniProt ID

Protein Blast

Polymer Type:polypeptide(L)
Molecule:Translation initiation factor
Gene (Uniprot):EIF2B1
Chain IDs:G, H
Chain Length:305
Number of Molecules:2
Biological Source:Homo sapiens

UniProt ID:Q14232 Pfam ID:PF01008

Structures with similar UniProt ID

Protein Blast

Polymer Type:polypeptide(L)
Molecule:Translation initiation factor
Gene (Uniprot):EIF2B3
Chain IDs:I, J
Chain Length:452
Number of Molecules:2
Biological Source:Homo sapiens

UniProt ID:Q9NR50 Pfam ID:PF00483, PF25084

Ligand Molecules