9Y44 image
Deposition Date 2025-09-02
Release Date 2026-02-18
Last Version Date 2026-02-18
Entry Detail
PDB ID:
9Y44
Keywords:
RIBOSOME
Title:
Structure of naked mole-rat ribosome (rotated, tRNAs, and mRNA)
Biological Source:
Source Organism(s):
Heterocephalus glaber (Taxon ID: 10181)
Method Details:
Experimental Method:
ELECTRON MICROSCOPY
Resolution:
4.90 Å
Aggregation State:
PARTICLE
Reconstruction Method:
SINGLE PARTICLE
9Y44 validation report missing
Macromolecular Entities
Structures with similar UniProt ID
Structural Superimposition Protein Blast
Polymer Type:polypeptide(L)
Molecule:Large ribosomal subunit prote
Gene (Uniprot):RPL8
Chain IDs:F (auth: A)
Chain Length:248
Number of Molecules:1
Biological Source:Heterocephalus glaber
UniProt ID:A0A0P6J3A4
Polymer Type:polyribonucleotide
Molecule:LSU alpha rRNA
Chain IDs:A (auth: A5)
Chain Length:1717
Number of Molecules:1
Biological Source:Heterocephalus glaber
Polymer Type:polyribonucleotide
Molecule:LSU beta rRNA
Chain IDs:E (auth: A6)
Chain Length:2092
Number of Molecules:1
Biological Source:Heterocephalus glaber
Polymer Type:polyribonucleotide
Molecule:5S ribosomal RNA
Chain IDs:B (auth: A7)
Chain Length:120
Number of Molecules:1
Biological Source:Heterocephalus glaber
Polymer Type:polyribonucleotide
Molecule:5.8S ribosomal RNA
Chain IDs:C (auth: A8)
Chain Length:156
Number of Molecules:1
Biological Source:Heterocephalus glaber
Structures with similar UniProt ID
Structural Superimposition Protein Blast
Polymer Type:polypeptide(L)
Molecule:Small ribosomal subunit prote
Gene (Uniprot):RPSA
Chain IDs:YA (auth: AA)
Chain Length:214
Number of Molecules:1
Biological Source:Heterocephalus glaber
UniProt ID:A0A0P6K1L6
Polymer Type:polypeptide(L)
Molecule:60S ribosomal protein L3
Chain IDs:H (auth: B)
Chain Length:398
Number of Molecules:1
Biological Source:Heterocephalus glaber
Polymer Type:polyribonucleotide
Molecule:18S ribosomal RNA
Chain IDs:D (auth: B2)
Chain Length:1804
Number of Molecules:1
Biological Source:Heterocephalus glaber
Polymer Type:polypeptide(L)
Molecule:40S ribosomal protein S3a
Chain IDs:ZA (auth: BB)
Chain Length:218
Number of Molecules:1
Biological Source:Heterocephalus glaber
Polymer Type:polyribonucleotide
Molecule:tRNA (65-MER)
Chain IDs:FC (auth: Bb)
Chain Length:65
Number of Molecules:1
Biological Source:Heterocephalus glaber
Structures with similar UniProt ID
Structural Superimposition Protein Blast
Polymer Type:polypeptide(L)
Molecule:Large ribosomal subunit prote
Gene (Uniprot):Rpl4
Chain IDs:I (auth: C)
Chain Length:363
Number of Molecules:1
Biological Source:Heterocephalus glaber
UniProt ID:G5AN81 Pfam ID:PF00573, PF14374
Polymer Type:polypeptide(L)
Molecule:40S ribosomal protein S2
Chain IDs:PB (auth: CC)
Chain Length:218
Number of Molecules:1
Biological Source:Heterocephalus glaber
Polymer Type:polyribonucleotide
Molecule:P/E tRNA
Chain IDs:EC (auth: Cc)
Chain Length:76
Number of Molecules:1
Biological Source:Heterocephalus glaber
Structures with similar UniProt ID
Structural Superimposition Protein Blast
Polymer Type:polypeptide(L)
Molecule:Large ribosomal subunit prote
Gene (Uniprot):Rpl5
Chain IDs:J (auth: D)
Chain Length:293
Number of Molecules:1
Biological Source:Heterocephalus glaber
UniProt ID:A0AAX6P0W2
Structures with similar UniProt ID
Structural Superimposition Protein Blast
Polymer Type:polypeptide(L)
Molecule:Small ribosomal subunit prote
Gene (Uniprot):RPS3
Chain IDs:AB (auth: DD)
Chain Length:225
Number of Molecules:1
Biological Source:Heterocephalus glaber
UniProt ID:G5AS76 Pfam ID:PF07650, PF00189 EC:4.2.99.18
Polymer Type:polyribonucleotide
Molecule:mRNA
Chain IDs:GC (auth: Dd)
Chain Length:13
Number of Molecules:1
Biological Source:Heterocephalus glaber
Polymer Type:polypeptide(L)
Molecule:60S ribosomal protein L6
Chain IDs:K (auth: E)
Chain Length:224
Number of Molecules:1
Biological Source:Heterocephalus glaber
Polymer Type:polypeptide(L)
Molecule:40S ribosomal protein S4, X i
Chain IDs:QB (auth: EE)
Chain Length:262
Number of Molecules:1
Biological Source:Heterocephalus glaber
Polymer Type:polypeptide(L)
Molecule:60S ribosomal protein L7
Chain IDs:L (auth: F)
Chain Length:225
Number of Molecules:1
Biological Source:Heterocephalus glaber
Structures with similar UniProt ID
Structural Superimposition Protein Blast
Polymer Type:polypeptide(L)
Molecule:Small ribosomal subunit prote
Gene (Uniprot):Rps5
Chain IDs:BB (auth: FF)
Chain Length:189
Number of Molecules:1
Biological Source:Heterocephalus glaber
UniProt ID:G5B7K7 Pfam ID:PF00177
Polymer Type:polypeptide(L)
Molecule:60S ribosomal protein L7a
Chain IDs:M (auth: G)
Chain Length:215
Number of Molecules:1
Biological Source:Heterocephalus glaber
Structures with similar UniProt ID
Structural Superimposition Protein Blast
Polymer Type:polypeptide(L)
Molecule:40S ribosomal protein S6
Gene (Uniprot):RPS6
Chain IDs:RB (auth: GG)
Chain Length:228
Number of Molecules:1
Biological Source:Heterocephalus glaber
UniProt ID:A0A0P6J125
Polymer Type:polypeptide(L)
Molecule:60S ribosomal protein L9
Chain IDs:N (auth: H)
Chain Length:190
Number of Molecules:1
Biological Source:Heterocephalus glaber
Structures with similar UniProt ID
Structural Superimposition Protein Blast
Polymer Type:polypeptide(L)
Molecule:40S ribosomal protein S7
Gene (Uniprot):Rps7
Chain IDs:SB (auth: HH)
Chain Length:190
Number of Molecules:1
Biological Source:Heterocephalus glaber
UniProt ID:G5C7L2 Pfam ID:PF01251
Structures with similar UniProt ID
Structural Superimposition Protein Blast
Polymer Type:polypeptide(L)
Molecule:60S ribosomal protein L10
Gene (Uniprot):Rpl10
Chain IDs:O (auth: I)
Chain Length:213
Number of Molecules:1
Biological Source:Heterocephalus glaber
UniProt ID:A0AAX6QHL6
Polymer Type:polypeptide(L)
Molecule:40S ribosomal protein S8
Chain IDs:TB (auth: II)
Chain Length:206
Number of Molecules:1
Biological Source:Heterocephalus glaber
Structures with similar UniProt ID
Structural Superimposition Protein Blast
Polymer Type:polypeptide(L)
Molecule:Large ribosomal subunit prote
Gene (Uniprot):Rpl11
Chain IDs:P (auth: J)
Chain Length:170
Number of Molecules:1
Biological Source:Heterocephalus glaber
UniProt ID:A0AAX6TFX7
Structures with similar UniProt ID
Structural Superimposition Protein Blast
Polymer Type:polypeptide(L)
Molecule:Small ribosomal subunit prote
Gene (Uniprot):Rps9
Chain IDs:UB (auth: JJ)
Chain Length:180
Number of Molecules:1
Biological Source:Heterocephalus glaber
UniProt ID:G5CBG2 Pfam ID:PF00163, PF01479
Structures with similar UniProt ID
Structural Superimposition Protein Blast
Polymer Type:polypeptide(L)
Molecule:Small ribosomal subunit prote
Gene (Uniprot):RPS10
Chain IDs:CB (auth: KK)
Chain Length:96
Number of Molecules:1
Biological Source:Heterocephalus glaber
UniProt ID:A0A0P6IZJ7
Polymer Type:polypeptide(L)
Molecule:60S ribosomal protein L13
Chain IDs:Q (auth: L)
Chain Length:205
Number of Molecules:1
Biological Source:Heterocephalus glaber
Structures with similar UniProt ID
Structural Superimposition Protein Blast
Polymer Type:polypeptide(L)
Molecule:Small ribosomal subunit prote
Gene (Uniprot):RPS11
Chain IDs:VB (auth: LL)
Chain Length:149
Number of Molecules:1
Biological Source:Heterocephalus glaber
UniProt ID:A0A0P6J0Q6
Structures with similar UniProt ID
Structural Superimposition Protein Blast
Polymer Type:polypeptide(L)
Molecule:Large ribosomal subunit prote
Gene (Uniprot):GW7_09170
Chain IDs:R (auth: M)
Chain Length:136
Number of Molecules:1
Biological Source:Heterocephalus glaber
UniProt ID:G5ALX1 Pfam ID:PF01929
Structures with similar UniProt ID
Structural Superimposition Protein Blast
Polymer Type:polypeptide(L)
Molecule:40S ribosomal protein S12
Gene (Uniprot):RPS12
Chain IDs:DB (auth: MM)
Chain Length:124
Number of Molecules:1
Biological Source:Heterocephalus glaber
UniProt ID:A0A0P6JDT6
Structures with similar UniProt ID
Structural Superimposition Protein Blast
Polymer Type:polypeptide(L)
Molecule:Ribosomal protein L15
Gene (Uniprot):Rpl15
Chain IDs:S (auth: N)
Chain Length:203
Number of Molecules:1
Biological Source:Heterocephalus glaber
UniProt ID:G5BFP9 Pfam ID:PF00827
Structures with similar UniProt ID
Structural Superimposition Protein Blast
Polymer Type:polypeptide(L)
Molecule:Small ribosomal subunit prote
Gene (Uniprot):Rps13
Chain IDs:WB (auth: NN)
Chain Length:149
Number of Molecules:1
Biological Source:Heterocephalus glaber
UniProt ID:G5B0I4 Pfam ID:PF08069, PF00312
Polymer Type:polypeptide(L)
Molecule:60S ribosomal protein L13a
Chain IDs:T (auth: O)
Chain Length:199
Number of Molecules:1
Biological Source:Heterocephalus glaber
Polymer Type:polypeptide(L)
Molecule:40S ribosomal protein S14
Chain IDs:EB (auth: OO)
Chain Length:134
Number of Molecules:1
Biological Source:Heterocephalus glaber
Polymer Type:polypeptide(L)
Molecule:60S ribosomal protein L17
Chain IDs:U (auth: P)
Chain Length:153
Number of Molecules:1
Biological Source:Heterocephalus glaber
Polymer Type:polypeptide(L)
Molecule:40S ribosomal protein S15
Chain IDs:FB (auth: PP)
Chain Length:118
Number of Molecules:1
Biological Source:Heterocephalus glaber
Structures with similar UniProt ID
Structural Superimposition Protein Blast
Polymer Type:polypeptide(L)
Molecule:60S ribosomal protein L18
Gene (Uniprot):Rpl18
Chain IDs:V (auth: Q)
Chain Length:187
Number of Molecules:1
Biological Source:Heterocephalus glaber
UniProt ID:G5B890 Pfam ID:PF17135
Structures with similar UniProt ID
Structural Superimposition Protein Blast
Polymer Type:polypeptide(L)
Molecule:Small ribosomal subunit prote
Gene (Uniprot):RPS16
Chain IDs:GB (auth: QQ)
Chain Length:141
Number of Molecules:1
Biological Source:Heterocephalus glaber
UniProt ID:G5BJD7 Pfam ID:PF00380
Structures with similar UniProt ID
Structural Superimposition Protein Blast
Polymer Type:polypeptide(L)
Molecule:Small ribosomal subunit prote
Gene (Uniprot):RPS17
Chain IDs:HB (auth: RR)
Chain Length:132
Number of Molecules:1
Biological Source:Heterocephalus glaber
UniProt ID:G5B1R5 Pfam ID:PF00833
Structures with similar UniProt ID
Structural Superimposition Protein Blast
Polymer Type:polypeptide(L)
Molecule:Large ribosomal subunit prote
Gene (Uniprot):RPL18A
Chain IDs:W (auth: S)
Chain Length:176
Number of Molecules:1
Biological Source:Heterocephalus glaber
UniProt ID:A0A0P6JCV6
Structures with similar UniProt ID
Structural Superimposition Protein Blast
Polymer Type:polypeptide(L)
Molecule:Small ribosomal subunit prote
Gene (Uniprot):GW7_20354
Chain IDs:IB (auth: SS)
Chain Length:145
Number of Molecules:1
Biological Source:Heterocephalus glaber
UniProt ID:G5BAZ4 Pfam ID:PF00416
Structures with similar UniProt ID
Structural Superimposition Protein Blast
Polymer Type:polypeptide(L)
Molecule:Large ribosomal subunit prote
Gene (Uniprot):RPL21
Chain IDs:X (auth: T)
Chain Length:159
Number of Molecules:1
Biological Source:Heterocephalus glaber
UniProt ID:G5ATV5 Pfam ID:PF01157
Structures with similar UniProt ID
Structural Superimposition Protein Blast
Polymer Type:polypeptide(L)
Molecule:Small ribosomal subunit prote
Gene (Uniprot):Rps19
Chain IDs:JB (auth: TT)
Chain Length:141
Number of Molecules:1
Biological Source:Heterocephalus glaber
UniProt ID:G5AZQ1 Pfam ID:PF01090
Polymer Type:polypeptide(L)
Molecule:60S ribosomal protein L22
Chain IDs:Y (auth: U)
Chain Length:99
Number of Molecules:1
Biological Source:Heterocephalus glaber
Polymer Type:polypeptide(L)
Molecule:40S ribosomal protein S20
Chain IDs:KB (auth: UU)
Chain Length:99
Number of Molecules:1
Biological Source:Heterocephalus glaber
Structures with similar UniProt ID
Structural Superimposition Protein Blast
Polymer Type:polypeptide(L)
Molecule:Large ribosomal subunit prote
Gene (Uniprot):Rpl23
Chain IDs:Z (auth: V)
Chain Length:131
Number of Molecules:1
Biological Source:Heterocephalus glaber
UniProt ID:G5BK67 Pfam ID:PF00238
Polymer Type:polypeptide(L)
Molecule:40S ribosomal protein S21
Chain IDs:XB (auth: VV)
Chain Length:83
Number of Molecules:1
Biological Source:Heterocephalus glaber
Structures with similar UniProt ID
Structural Superimposition Protein Blast
Polymer Type:polypeptide(L)
Molecule:Ribosomal protein L19
Gene (Uniprot):Rpl19
Chain IDs:BC (auth: W)
Chain Length:180
Number of Molecules:1
Biological Source:Heterocephalus glaber
UniProt ID:G5BRW3 Pfam ID:PF01280, PF25476
Structures with similar UniProt ID
Structural Superimposition Protein Blast
Polymer Type:polypeptide(L)
Molecule:Small ribosomal subunit prote
Gene (Uniprot):RPS15A
Chain IDs:YB (auth: WW)
Chain Length:129
Number of Molecules:1
Biological Source:Heterocephalus glaber
UniProt ID:G5AY31 Pfam ID:PF00410
Structures with similar UniProt ID
Structural Superimposition Protein Blast
Polymer Type:polypeptide(L)
Molecule:Large ribosomal subunit prote
Gene (Uniprot):Rpl23a
Chain IDs:AA (auth: X)
Chain Length:118
Number of Molecules:1
Biological Source:Heterocephalus glaber
UniProt ID:A0AAX6PQW7
Polymer Type:polypeptide(L)
Molecule:40S ribosomal protein S23
Chain IDs:ZB (auth: XX)
Chain Length:122
Number of Molecules:1
Biological Source:Heterocephalus glaber
Polymer Type:polypeptide(L)
Molecule:60S ribosomal protein L26
Chain IDs:BA (auth: Y)
Chain Length:134
Number of Molecules:1
Biological Source:Heterocephalus glaber
Structures with similar UniProt ID
Structural Superimposition Protein Blast
Polymer Type:polypeptide(L)
Molecule:40S ribosomal protein S24
Gene (Uniprot):Rps24
Chain IDs:AC (auth: YY)
Chain Length:125
Number of Molecules:1
Biological Source:Heterocephalus glaber
UniProt ID:A0AAX6T3G5
Structures with similar UniProt ID
Structural Superimposition Protein Blast
Polymer Type:polypeptide(L)
Molecule:60S ribosomal protein L27
Gene (Uniprot):RPL27
Chain IDs:CA (auth: Z)
Chain Length:135
Number of Molecules:1
Biological Source:Heterocephalus glaber
UniProt ID:G5BN91 Pfam ID:PF00467, PF01777
Structures with similar UniProt ID
Structural Superimposition Protein Blast
Polymer Type:polypeptide(L)
Molecule:40S ribosomal protein S25
Gene (Uniprot):RPS25
Chain IDs:LB (auth: ZZ)
Chain Length:75
Number of Molecules:1
Biological Source:Heterocephalus glaber
UniProt ID:A0A0P6J730
Polymer Type:polypeptide(L)
Molecule:60S ribosomal protein L27a
Chain IDs:DA (auth: a)
Chain Length:147
Number of Molecules:1
Biological Source:Heterocephalus glaber
Polymer Type:polypeptide(L)
Molecule:40S ribosomal protein S26
Chain IDs:OB (auth: aa)
Chain Length:98
Number of Molecules:1
Biological Source:Heterocephalus glaber
Polymer Type:polypeptide(L)
Molecule:60S ribosomal protein L29
Chain IDs:EA (auth: b)
Chain Length:100
Number of Molecules:1
Biological Source:Heterocephalus glaber
Structures with similar UniProt ID
Structural Superimposition Protein Blast
Polymer Type:polypeptide(L)
Molecule:40S ribosomal protein S27
Gene (Uniprot):Rps27
Chain IDs:MB (auth: bb)
Chain Length:82
Number of Molecules:1
Biological Source:Heterocephalus glaber
UniProt ID:E3VX74 Pfam ID:PF01667
Structures with similar UniProt ID
Structural Superimposition Protein Blast
Polymer Type:polypeptide(L)
Molecule:Large ribosomal subunit prote
Gene (Uniprot):Rpl24
Chain IDs:CC (auth: c)
Chain Length:121
Number of Molecules:1
Biological Source:Heterocephalus glaber
UniProt ID:G5C020 Pfam ID:PF01246
Polymer Type:polypeptide(L)
Molecule:40S ribosomal protein S28
Chain IDs:UA (auth: cc)
Chain Length:61
Number of Molecules:1
Biological Source:Heterocephalus glaber
Structures with similar UniProt ID
Structural Superimposition Protein Blast
Polymer Type:polypeptide(L)
Molecule:Large ribosomal subunit prote
Gene (Uniprot):RPL31
Chain IDs:FA (auth: d)
Chain Length:107
Number of Molecules:1
Biological Source:Heterocephalus glaber
UniProt ID:A0A0N8ESF6
Structures with similar UniProt ID
Structural Superimposition Protein Blast
Polymer Type:polypeptide(L)
Molecule:Small ribosomal subunit prote
Gene (Uniprot):RPS29
Chain IDs:XA (auth: dd)
Chain Length:55
Number of Molecules:1
Biological Source:Heterocephalus glaber
UniProt ID:A0A0P6JEN2
Structures with similar UniProt ID
Structural Superimposition Protein Blast
Polymer Type:polypeptide(L)
Molecule:60S ribosomal protein L32
Gene (Uniprot):Rpl32
Chain IDs:GA (auth: e)
Chain Length:128
Number of Molecules:1
Biological Source:Heterocephalus glaber
UniProt ID:G5BYD8 Pfam ID:PF01655
Polymer Type:polypeptide(L)
Molecule:40S ribosomal protein S30
Chain IDs:NB (auth: ee)
Chain Length:49
Number of Molecules:1
Biological Source:Heterocephalus glaber
Structures with similar UniProt ID
Structural Superimposition Protein Blast
Polymer Type:polypeptide(L)
Molecule:Large ribosomal subunit prote
Gene (Uniprot):RPL35A
Chain IDs:HA (auth: f)
Chain Length:110
Number of Molecules:1
Biological Source:Heterocephalus glaber
UniProt ID:A0A0P6J939
Structures with similar UniProt ID
Structural Superimposition Protein Blast
Polymer Type:polypeptide(L)
Molecule:Ubiquitin-ribosomal protein e
Gene (Uniprot):Rps27a
Chain IDs:VA (auth: ff)
Chain Length:67
Number of Molecules:1
Biological Source:Heterocephalus glaber
UniProt ID:G5B8W4 Pfam ID:PF01599
Structures with similar UniProt ID
Structural Superimposition Protein Blast
Polymer Type:polypeptide(L)
Molecule:Large ribosomal subunit prote
Gene (Uniprot):Rpl34
Chain IDs:IA (auth: g)
Chain Length:110
Number of Molecules:1
Biological Source:Heterocephalus glaber
UniProt ID:G5AQL2 Pfam ID:PF01199
Structures with similar UniProt ID
Structural Superimposition Protein Blast
Polymer Type:polypeptide(L)
Molecule:Small ribosomal subunit prote
Gene (Uniprot):GNB2L1
Chain IDs:WA (auth: gg)
Chain Length:313
Number of Molecules:1
Biological Source:Heterocephalus glaber
UniProt ID:A0A0P6J231
Structures with similar UniProt ID
Structural Superimposition Protein Blast
Polymer Type:polypeptide(L)
Molecule:Large ribosomal subunit prote
Gene (Uniprot):RPL35
Chain IDs:JA (auth: h)
Chain Length:121
Number of Molecules:1
Biological Source:Heterocephalus glaber
UniProt ID:G5B6W3 Pfam ID:PF00831
Polymer Type:polypeptide(L)
Molecule:60S ribosomal protein L36
Chain IDs:KA (auth: i)
Chain Length:102
Number of Molecules:1
Biological Source:Heterocephalus glaber
Structures with similar UniProt ID
Structural Superimposition Protein Blast
Polymer Type:polypeptide(L)
Molecule:Ribosomal protein L37
Gene (Uniprot):RPL37
Chain IDs:LA (auth: j)
Chain Length:86
Number of Molecules:1
Biological Source:Heterocephalus glaber
UniProt ID:A0A0P6JT91
Structures with similar UniProt ID
Structural Superimposition Protein Blast
Polymer Type:polypeptide(L)
Molecule:Large ribosomal subunit prote
Gene (Uniprot):RPL38
Chain IDs:MA (auth: k)
Chain Length:69
Number of Molecules:1
Biological Source:Heterocephalus glaber
UniProt ID:A0A0P6IYP5
Structures with similar UniProt ID
Structural Superimposition Protein Blast
Polymer Type:polypeptide(L)
Molecule:Large ribosomal subunit prote
Gene (Uniprot):LOC101707773
Chain IDs:NA (auth: l)
Chain Length:50
Number of Molecules:1
Biological Source:Heterocephalus glaber
UniProt ID:A0AAX6NYH3
Structures with similar UniProt ID
Structural Superimposition Protein Blast
Polymer Type:polypeptide(L)
Molecule:Ubiquitin-ribosomal protein e
Gene (Uniprot):Uba52
Chain IDs:OA (auth: m)
Chain Length:51
Number of Molecules:1
Biological Source:Heterocephalus glaber
UniProt ID:G5C5A6 Pfam ID:PF01020
Structures with similar UniProt ID
Structural Superimposition Protein Blast
Polymer Type:polypeptide(L)
Molecule:60S ribosomal protein L41
Gene (Uniprot):RPL41
Chain IDs:G (auth: n)
Chain Length:25
Number of Molecules:1
Biological Source:Heterocephalus glaber
UniProt ID:A0A0P6J950
Structures with similar UniProt ID
Structural Superimposition Protein Blast
Polymer Type:polypeptide(L)
Molecule:60S ribosomal protein L36a
Gene (Uniprot):Rpl36al
Chain IDs:PA (auth: o)
Chain Length:105
Number of Molecules:1
Biological Source:Heterocephalus glaber
UniProt ID:G5BW65 Pfam ID:PF00935
Structures with similar UniProt ID
Structural Superimposition Protein Blast
Polymer Type:polypeptide(L)
Molecule:Large ribosomal subunit prote
Gene (Uniprot):Rpl37a
Chain IDs:QA (auth: p)
Chain Length:91
Number of Molecules:1
Biological Source:Heterocephalus glaber
UniProt ID:E3VX70 Pfam ID:PF01780
Structures with similar UniProt ID
Structural Superimposition Protein Blast
Polymer Type:polypeptide(L)
Molecule:Large ribosomal subunit prote
Gene (Uniprot):RPL28
Chain IDs:RA (auth: r)
Chain Length:127
Number of Molecules:1
Biological Source:Heterocephalus glaber
UniProt ID:G5BVZ2 Pfam ID:PF01778
Polymer Type:polypeptide(L)
Molecule:60S acidic ribosomal protein
Chain IDs:SA (auth: s)
Chain Length:103
Number of Molecules:1
Biological Source:Heterocephalus glaber
Polymer Type:polypeptide(L)
Molecule:60S ribosomal protein L12
Chain IDs:TA (auth: t)
Chain Length:156
Number of Molecules:1
Biological Source:Heterocephalus glaber
Structures with similar UniProt ID
Structural Superimposition Protein Blast
Polymer Type:polypeptide(L)
Molecule:Large ribosomal subunit prote
Gene (Uniprot):RPL30
Chain IDs:DC (auth: u)
Chain Length:100
Number of Molecules:1
Biological Source:Heterocephalus glaber
UniProt ID:G5B8Y2 Pfam ID:PF01248
Modified Residue
Compound ID Chain ID Parent Comp ID Details 2D Image
M3L OA LYS modified residue
MLZ PA LYS modified residue
NMM JB ARG modified residue
Ligand Molecules
MG
ZN
Primary Citation
Structures of naked mole-rat, tuco-tuco, and guinea pig ribosomes-is rRNA fragmentation linked to translational fidelity?
Nucleic Acids Res. 54 ? ? (2026)
PMID: 41603730 DOI: 10.1093/nar/gkag006

Abstact

Ribosomes are central to protein synthesis in all organisms. In mammals, the ribosome functional core is highly conserved. Remarkably, two rodent species, the naked mole-rat (NMR) and tuco-tuco, display fragmented 28S ribosomal RNA (rRNA), coupled with high translational fidelity and long lifespan. The unusual ribosomal architecture in the NMR and tuco-tuco has been speculated to be linked to high translational fidelity. Here, we show, by single-particle cryo-electron microscopy, that despite the fragmentation of their rRNA, NMR and tuco-tuco ribosomes retain their core functional architecture. Compared to ribosomes of the guinea pig, a phylogenetically related rodent without 28S rRNA fragmentation, ribosomes of NMR and tuco-tuco exhibit poorly resolved density for certain expansion segments. In contrast, the structure of the guinea pig ribosome shows high similarity to the human ribosome. Enhanced translational fidelity in the NMR and tuco-tuco may stem from subtle, allosteric effects in dynamics, linked to rRNA fragmentation.

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Disease

Primary Citation of related structures
9Y44
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