ISDA: 9Y3Q

Deposition Date 2025-09-02

Release Date 2026-06-24

Last Version Date 2026-06-24

Entry Detail

PDB ID:

9Y3Q

Keywords:

TRANSLATION

Title:

Eukaryotic translation initiation factor 2-B in its apo form (inactive-state)

Biological Source:

Source Organism(s):

Homo sapiens (Taxon ID: 9606)

Expression System(s):

Escherichia coli

Method Details:

Experimental Method:

ELECTRON MICROSCOPY

Resolution:

3.30 Å

Aggregation State:

PARTICLE

Reconstruction Method:

SINGLE PARTICLE

Download Validation Report

Macromolecular Entities

Structures with similar UniProt ID

Protein Blast

Polymer Type:polypeptide(L)
Molecule:Translation initiation factor
Gene (Uniprot):EIF2B5
Chain IDs:A, F (auth: B)
Chain Length:721
Number of Molecules:2
Biological Source:Homo sapiens

UniProt ID:Q13144 Pfam ID:PF02020

Structures with similar UniProt ID

Protein Blast

Polymer Type:polypeptide(L)
Molecule:Translation initiation factor
Gene (Uniprot):EIF2B2
Chain IDs:B (auth: C), G (auth: D)
Chain Length:368
Number of Molecules:2
Biological Source:Homo sapiens

UniProt ID:P49770 Pfam ID:PF01008

Structures with similar UniProt ID

Protein Blast

Polymer Type:polypeptide(L)
Molecule:Translation initiation factor
Gene (Uniprot):EIF2B4
Chain IDs:C (auth: E), H (auth: F)
Chain Length:523
Number of Molecules:2
Biological Source:Homo sapiens

UniProt ID:Q9UI10 Pfam ID:PF01008

Structures with similar UniProt ID

Protein Blast

Polymer Type:polypeptide(L)
Molecule:Translation initiation factor
Gene (Uniprot):EIF2B1
Chain IDs:D (auth: G), I (auth: H)
Chain Length:305
Number of Molecules:2
Biological Source:Homo sapiens

UniProt ID:Q14232 Pfam ID:PF01008

Structures with similar UniProt ID

Protein Blast

Polymer Type:polypeptide(L)
Molecule:Translation initiation factor
Gene (Uniprot):EIF2B3
Chain IDs:E (auth: I), J
Chain Length:452
Number of Molecules:2
Biological Source:Homo sapiens

UniProt ID:Q9NR50 Pfam ID:PF00483, PF25084

Ligand Molecules

Primary Citation

Allosteric Disordering of eIF2B Regulates the Integrated Stress Response

Dalwadi, U, Subramanian, A, Croll, T, Lee, D.J, Arthur, C, Walter, P, Frost, A.Show

To Be Published ? ? ? (?)

Primary Citation of related structures

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