ISDA: 9Y3K

Deposition Date 2025-09-02

Release Date 2026-07-22

Last Version Date 2026-07-22

Entry Detail

PDB ID:

9Y3K

Keywords:

TRANSFERASE

Title:

Crystal Structure of Human Ornithine Aminotransferase Pre-Inactivated by CPP115 (Tight Binding)

Biological Source:

Source Organism(s):

Homo sapiens (Taxon ID: 9606)

Expression System(s):

Escherichia coli

Method Details:

Experimental Method:

X-RAY DIFFRACTION

Resolution:

2.15 Å

R-Value Free:

0.20

R-Value Work:

0.16

R-Value Observed:

0.16

Space Group:

P 32 2 1

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Macromolecular Entities

Structures with similar UniProt ID

Structural Superimposition Protein Blast

Polymer Type:polypeptide(L)
Molecule:Ornithine aminotransferase, m
Gene (Uniprot):OAT
Chain IDs:A, B, C
Chain Length:404
Number of Molecules:3
Biological Source:Homo sapiens

UniProt ID:P04181 Pfam ID:PF00202 EC:2.6.1.13

Ligand Molecules

RW2

Primary Citation

Targeting Conformational Flexibility of a Reactive Intermediate to Enhance Selectivity of a GABA Aminotransferase Inactivator.

Kang, K.M, Vargas, A.L, Ferreira, L.A, Des Soye, B.J, Corrigan, M, Zhang, C.K, Wang, F, Duan, D, Kelleher, N.L, Hohmann, A.G, Liu, D, Silverman, R.B.Show

J.Am.Chem.Soc. 148 8736 8748 (2026)

PMID: 41711325 DOI: 10.1021/jacs.5c21138

Primary Citation of related structures

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