ISDA: 9Y3A

Deposition Date 2025-09-02

Release Date 2026-08-26

Last Version Date 2026-08-26

Entry Detail

PDB ID:

9Y3A

Keywords:

OXIDOREDUCTASE

Title:

Human malic enzyme 1 complex with NADP+ at 1.9 Angstrom.

Biological Source:

Source Organism(s):

Homo sapiens (Taxon ID: 9606)

Expression System(s):

Escherichia coli

Method Details:

Experimental Method:

X-RAY DIFFRACTION

Resolution:

1.91 Å

R-Value Free:

0.22

R-Value Work:

0.19

Space Group:

P 1 21 1

Download Validation Report

Macromolecular Entities

Polymer Type:polypeptide(L)
Molecule:NADP-dependent malic enzyme
Chain IDs:A, B, C, D
Chain Length:580
Number of Molecules:4
Biological Source:Homo sapiens

Ligand Molecules

EDO

NAP

Primary Citation

A cryptic allosteric pocket shapes isoform-selective inhibition of human malic enzymes.

Krinkel, B.A, Yosaatmadja, Y, Slayton, M.D, Krinkel, A, Copping, J, Jeon, J.H, Eu, J, Kohagen, K, Ashoorzadeh, A, Smaill, J, Flanagan, J, Walker, C, Merajver, S.D, Loomes, K, Squire, C.J.Show

Protein Sci. 35 e70757 e70757 (2026)

PMID: 42581399 DOI: 10.1002/pro.70757

Primary Citation of related structures

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