9Y1Q image
Deposition Date 2025-08-30
Release Date 2026-09-09
Last Version Date 2026-09-09
Entry Detail
PDB ID:
9Y1Q
Keywords:
MEMBRANE PROTEIN
Title:
Alternative NBD1-binding geometry in channel-formed, ATP-bound, VX809-bound, T2a-nanobody-bound wild-type human CFTR (Composite map from PHENIX)
Biological Source:
Source Organism(s):
Homo sapiens (Taxon ID: 9606)
Lama glama (Taxon ID: 9844)
Expression System(s):
Cricetulus griseus, Escherichia coli
Method Details:
Experimental Method:
ELECTRON MICROSCOPY
Resolution:
3.86 Å
Aggregation State:
PARTICLE
Reconstruction Method:
SINGLE PARTICLE
9Y1Q validation report missing
Macromolecular Entities
Structures with similar UniProt ID
Structural Superimposition Protein Blast
Polymer Type:polypeptide(L)
Molecule:Cystic fibrosis transmembrane
Gene (Uniprot):CFTR
Chain IDs:A
Chain Length:1523
Number of Molecules:1
Biological Source:Homo sapiens
UniProt ID:P13569 Pfam ID:PF00664, PF00005, PF14396 EC:2.7.4.3
Polymer Type:polypeptide(L)
Molecule:T2a nanobody
Chain IDs:B
Chain Length:146
Number of Molecules:1
Biological Source:Lama glama
Polymer Type:polypeptide(L)
Molecule:UNK-UNK-UNK-UNK-UNK-UNK-UNK-U
Chain IDs:C
Chain Length:17
Number of Molecules:1
Biological Source:Homo sapiens
Ligand Molecules
3PH
AJP
ATP
CLR
D10
D12
HEX
MG
MYR
OCT
P5S
PC1
PLM
PTY
VX8
Primary Citation
Nanobody-Driven Stabilization Synergistically Rescues F508del-CFTR and Reveals an Alternative Active State of the Channel
To Be Published ? ? ? (?)
Primary Citation of related structures
9Y1Q
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