ISDA: 9Y05

Deposition Date 2025-08-28

Release Date 2026-04-29

Last Version Date 2026-04-29

Entry Detail

PDB ID:

9Y05

Keywords:

HYDROLASE

Title:

Cryo-EM structure of human VCP/p97-R89W mutant bound to CB-5083

Biological Source:

Source Organism(s):

Homo sapiens (Taxon ID: 9606)

Expression System(s):

Escherichia coli bl21(de3)

Method Details:

Experimental Method:

ELECTRON MICROSCOPY

Resolution:

2.58 Å

Aggregation State:

PARTICLE

Reconstruction Method:

SINGLE PARTICLE

Download Validation Report

Macromolecular Entities

Structures with similar UniProt ID

Protein Blast

Polymer Type:polypeptide(L)
Molecule:Transitional endoplasmic reti
Gene (Uniprot):VCP
Mutagens:R89W
Chain IDs:A, B, C, D, E, F, G, H, I, J, K, L
Chain Length:822
Number of Molecules:12
Biological Source:Homo sapiens

UniProt ID:P55072 EC:3.6.4.6

Ligand Molecules

JDP

Primary Citation

Mutations in VCP cause Adams-Oliver syndrome with or without pulmonary hypertension.

Lehman, A, Ahmed, S, Mohajeri, A, Berezuk, A.M, Mannar, D, Cholak, S, Tuttle, K.S, Bennett, J.T, Aparecida Magno, J, Hannibal, M, Kovacevic, G, Kuburovic, V, Suzanne Lewis, M.E, Moldovan, O, Nelson, Z, Raskin, S, Vandersteen, A.M, Roach, J.C, Subramaniam, S, Patel, M.S.Show

Genet Med ? 102579 102579 (2026)

PMID: 41979051 DOI: 10.1016/j.gim.2026.102579

Primary Citation of related structures

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