ISDA: 9XZE

Deposition Date 2025-08-27

Release Date 2026-09-02

Last Version Date 2026-09-02

Entry Detail

PDB ID:

9XZE

Keywords:

LIGASE

Title:

E3 ubiquitin-protein ligase CBL-B in complex with compound 9

Biological Source:

Source Organism(s):

Homo sapiens (Taxon ID: 9606)

Expression System(s):

Escherichia coli

Method Details:

Experimental Method:

X-RAY DIFFRACTION

Resolution:

2.00 Å

R-Value Free:

0.24

R-Value Work:

0.19

R-Value Observed:

0.20

Space Group:

P 21 21 21

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Macromolecular Entities

Structures with similar UniProt ID

Structural Superimposition Protein Blast

Polymer Type:polypeptide(L)
Molecule:E3 ubiquitin-protein ligase C
Gene (Uniprot):CBLB
Chain IDs:A
Chain Length:0
Number of Molecules:1
Biological Source:Homo sapiens

UniProt ID:Q13191 Pfam ID:PF02262, PF02761, PF02762, PF00097 EC:2.3.2.27

Ligand Molecules

EDO

SO4

XLU

Primary Citation

Discovery and characterization of Cbl-b intra-molecular inhibitory glues with biological activity.

Gajewski, S.Show

To Be Published ? ? ? (?)

Primary Citation of related structures

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