ISDA: 9XYJ

Deposition Date 2025-08-26

Release Date 2026-10-14

Last Version Date 2026-10-14

Entry Detail

PDB ID:

9XYJ

Keywords:

HYDROLASE

Title:

Human mitochondrial ClpP V62A variant

Biological Source:

Source Organism(s):

Homo sapiens (Taxon ID: 9606)

Expression System(s):

Escherichia coli bl21(de3)

Method Details:

Experimental Method:

ELECTRON MICROSCOPY

Resolution:

3.20 Å

Aggregation State:

PARTICLE

Reconstruction Method:

SINGLE PARTICLE

Download Validation Report

Macromolecular Entities

Structures with similar UniProt ID

Structural Superimposition Protein Blast

Polymer Type:polypeptide(L)
Molecule:ATP-dependent Clp protease pr
Gene (Uniprot):CLPP
Mutagens:V62A
Chain IDs:A, B, C, D, E, F, G
Chain Length:221
Number of Molecules:7
Biological Source:Homo sapiens

UniProt ID:Q16740 EC:3.4.21.92

Ligand Molecules

Primary Citation

Allosteric inhibition of human mitochondrial ClpP by hijacking the dordaviprone (ONC201) binding site

Goncalves, M.M, Uday, A.B, Watson, I.D.G, Chau, A.M, Kalhor-Monfared, S, Wan, B, Kiyota, T, Currie, S.Q.W, Jitkova, Y, Feng, Y, Diamandas, M, Ling, D, Ma, M, Mancini, R.S, Wang, Z, Casas-Selves, M, Joshi, D, Mohammed, M, Subramaniam, R, Fernandes, E.L, Yan, Y, Pomroy, N, Hurren, R, Gronda, M, Velyvis, A, Yudin, A.K, Reed, M.A, Prive, G, Aman, A, Isaac, M, Marcellus, R, Uehling, D, Schimmer, A.D, Zeytuni, N, Vahidi, S.Show

Nat Commun ? ? ? (2026)

DOI: 10.1038/s41467-026-78140-5

Primary Citation of related structures

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