ISDA: 9XW8

Deposition Date 2025-11-27

Release Date 2026-09-23

Last Version Date 2026-09-23

Entry Detail

PDB ID:

9XW8

Keywords:

STRUCTURAL PROTEIN

Title:

Cryo-EM structure of PI3Kalpha E542K mutation in complex with STX-478

Biological Source:

Source Organism(s):

Homo sapiens (Taxon ID: 9606)

Expression System(s):

Trichoplusia ni

Method Details:

Experimental Method:

ELECTRON MICROSCOPY

Resolution:

2.86 Å

Aggregation State:

PARTICLE

Reconstruction Method:

SINGLE PARTICLE

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Macromolecular Entities

Structures with similar UniProt ID

Structural Superimposition Protein Blast

Polymer Type:polypeptide(L)
Molecule:Phosphatidylinositol 4,5-bisp
Gene (Uniprot):PIK3CA
Chain IDs:A
Chain Length:1096
Number of Molecules:1
Biological Source:Homo sapiens

UniProt ID:P42336 Pfam ID:PF02192, PF00794, PF00792, PF00613, PF00454 EC:2.7.1.137

Ligand Molecules

ZWE

Primary Citation

Molecular architecture responsible for specific inhibition of oncogenic PI3K alpha mutants by RLY-2608 and STX-478

Liu, X, Chen, Y, Li, G, Chen, A, Zhou, Q, Wang, M.W.Show

Acta Pharm Sin B ? ? ? (2026)

DOI: 10.1016/j.apsb.2026.07.003

Primary Citation of related structures

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