9XW0 image
Deposition Date 2025-11-27
Release Date 2026-08-26
Last Version Date 2026-08-26
Entry Detail
PDB ID:
9XW0
Keywords:
SIGNALING PROTEIN
Title:
Crystal structure of the TNIK-TK7 peptide complex
Biological Source:
Source Organism(s):
Homo sapiens (Taxon ID: 9606)
synthetic construct (Taxon ID: 32630)
Expression System(s):
Escherichia coli
Method Details:
Experimental Method:
X-RAY DIFFRACTION
Resolution:
2.40 Å
R-Value Free:
0.24
R-Value Work:
0.20
R-Value Observed:
0.20
Space Group:
P 1 21 1
9XW0 validation report missing
Macromolecular Entities
Polymer Type:polypeptide(L)
Molecule:TRAF2 and NCK-interacting pro
Chain IDs:A, B (auth: C)
Chain Length:306
Number of Molecules:2
Biological Source:Homo sapiens
Polymer Type:polypeptide(L)
Molecule:peptide TK7
Chain IDs:C (auth: B), D
Chain Length:16
Number of Molecules:2
Biological Source:synthetic construct
Modified Residue
Compound ID Chain ID Parent Comp ID Details 2D Image
TPO A THR modified residue
Ligand Molecules
NA
Primary Citation
De Novo Discovery of Nonstandard Thioisoindole-Bridged Bicyclic Peptides Targeting Traf2- and NCK-Interacting Kinase.
Angew.Chem.Int.Ed.Engl. ? e2417165 e2417165 (2026)
PMID: 42593841 DOI: 10.1002/anie.2417165
Primary Citation of related structures
9XW0
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